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Diss Factsheets
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EC number: 605-539-0 | CAS number: 169115-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: group entry
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Material on the substantiation of the maximum allowable concentrations of mono-, di-, and triisopropanolamine in the air of a work area
- Author:
- Burkatskaya EN
- Year:
- 1 986
- Bibliographic source:
- Gigiena Truda i Professional nye Zabolevarija 30, 46-48, 1986
- Reference Type:
- secondary source
- Title:
- 1-Aminopropan-2-ol (Monoisopropanolamin, MIPA) CAS-Nr. 78-96-6
- Author:
- Ausschuss für Gefahrstoffe
- Year:
- 2 006
- Bibliographic source:
- BAuA - Begründungen zu Arbeitsplatzgrenzwerten, Technische Regeln für Gefahrstoffe, 1-Aminopropan-2-ol in TRGS 900; web-page
- Reference Type:
- publication
- Title:
- Range finding toxicity data: List IV
- Author:
- Smyth HF
- Year:
- 1 951
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine 4, 119-122, 1951
- Reference Type:
- secondary source
- Title:
- 2-Propanol, 1-amino-, CAS-No. 78-96-6; SIDS Initial Assessment Profile for SIAM 32, 2011-04-19; Investigated in a Category C1-13 Primary Amines
- Author:
- OECD SIDS
- Year:
- 2 011
- Bibliographic source:
- OECD SIDS documents (Chemicals Screening Information Dataset for High Volume Chemicals); Conclusions agreed; available via web-page
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
- Reference Type:
- secondary source
- Title:
- Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed isopropanolamine
- Author:
- JACT
- Year:
- 1 987
- Bibliographic source:
- Journal of the Americal College of Toxicology, Volume 6, No. 1, 53-76, 1987
Materials and methods
- Principles of method if other than guideline:
- old methods for acute oral toxicity testing
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- IUPAC Name:
- 1-aminopropan-2-ol
- Reference substance name:
- 1-amino-2-propanol
- IUPAC Name:
- 1-amino-2-propanol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- LD50
- Effect level:
- 1 715 mg/kg bw
- Remarks on result:
- other: reduced body temperature, diarrhoea, drowsiness
- Dose descriptor:
- LD50
- Effect level:
- 4 260 mg/kg bw
- Dose descriptor:
- LD50
- Effect level:
- 2 813 mg/kg bw
- Remarks on result:
- other: aqueous solutions of 2, 20, and 30% were administered; clinical symptoms: agitation, staggering gait, dispnoea, convulsions; macroscopic signs: none
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 098 mg/kg bw
- Remarks on result:
- other: groups of 6 rats were given 500 to 3500 mg/kg bw of the test substance; all rats were lethargic and had diarrhea and rough hair coats; no treatment related effects were observed upon pathological examination at the end of the 2 week observation period.
Applicant's summary and conclusion
- Executive summary:
Various early acute oral toxicity studies not performed under GLP in summary show an LD50 of > 2000 mg/kg bw for 1-amino-2-propanol in rats. Clinical signs were reported as e.g. diarrhea, rough hair coats and lethargic behaviour.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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