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EC number: 231-193-1 | CAS number: 7446-07-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Tellurium-Induced Neuropathy: metabolic alternations associated with demyelination and remyelination in rat sciatic nerve
- Author:
- Harry G.J., CoodrumJ.J, Bouldin T.W., Wagner-Recio M., Toews A.D.,and Morell P.
- Year:
- 1 989
- Bibliographic source:
- Journal of Neurochemistry 52(3): 938-945
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
animal model to study myelination/ demyelination of schwann cells
- Short description of test conditions: animals were fed for 7 days with Tellurium containing chow and effects were analyses at different times ranging from 1 to 30 days following initiation of the treatment.
- Parameters analysed / observed:
morphological analysis: ultrastructural alterations of the sciatic nerves
in vitro studies/ biochemical analysis: capacity of the sciatic nerve segments to synthesie lipids (incorporation of radioactive acetate / glycerol ). - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Specific details on test material used for the study:
- Elemental Tellurium powder (60 mesh, 99% pure (alfa Products, Danvers, MA,USA)
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- pre-pubertal animals (17 days) , maintained at constant room temperature of 21 +/-2°C , relative humidity 50 +/- 10% , 12h light/dark
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- start treatment at 20 days of age
- Duration of treatment / exposure:
- 7 consecutive days
- Frequency of treatment:
- continues free access to supplemented chow
- Duration of test:
- 1 to 30 days
Doses / concentrations
- Dose / conc.:
- 12 500 mg/kg diet
- Remarks:
- + minimal amount of corn oil to prevent separation
- No. of animals per sex per dose:
- male rats from 6 litters (random distribution over treatment / control group)
- Control animals:
- yes, concurrent vehicle
Results and discussion
Observed effects
Observed metabolic alterations:
- a rapid and massive accumulation of ['4C]acetate-derived radioactivity in squalene (23% of total lipid radioactivity after 1 day of tellurium treat- ment, compared to ~0.5% in controls).
- the marked decrease in overall incorporation of radioactive acetate into lipids during the demyelinating phase of tellurium neuropathy.
- There was a preferential decrease in the incorporation of label into cerebrosides and ethanolamine plas- malogens, lipids which are enriched in myelin.
- a (twofold) increase in reesterification of fatty acids into glycerolipids
Within 30 days of beginning a 7-day exposure to tellurium, remyelination was complete and our assay system no longer detected metabolic alterations in lipid synthesis in nerve.
Applicant's summary and conclusion
- Conclusions:
- From this paper only the relevant information and results, that could have an impact on the reproductive function are included in this summary.
- Executive summary:
The tellurium induced observed effect, points to the inhibition of squalene epioxidase activity, an enzyme in the cholesterol synthesis pathway. Cholesterol is a precursor in the steroidogenesis pathway, but is not a rate limiting factor.
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