Registration Dossier
Registration Dossier
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EC number: 268-028-8 | CAS number: 67990-05-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publications which meet basic scientific principles
Data source
Materials and methods
- Type of study / information:
- Information on photochemical cleavage Pigment Red 22
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- not specified
Results and discussion
Any other information on results incl. tables
Experiment I:
After UVB-irradiation of PR 22 in solvents the decomposition products 2-methyl-5-nitroaniline (2,5 -MNA), 4 -nitrotoluene (4 -NT) were detectable. After sunlight exposure either 2,5 -MNA and 4 -NT or neither pigment nor decomposition products were detectable, depending on the solvent used. These data indicate that sunlight can cause complete mineralization.
Experiment II:
Pigment reduction during 42 days was about
- 32% in untreated skin;
- 60% in solar light treated skin;
- 51% in laser treated skin.
In laser treated skin 2-methyl-5-nitroaniline (2,5 -MNA), 4 -nitrotoluene (4 -NT) and naphtol AS (NAS) were detectable as decomposition products. The authors calculated that about 8% of decomposed PR 22 was directly detected as 2,5 -MNA and 4 -NT.
In solar light treated skin no 2,5 -MNA and 4 -NT products were detectable.
Applicant's summary and conclusion
- Conclusions:
- In vitro and in vivo investigations revealed that Pigment Red 22 can be decomposed by laser and sunlight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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