Registration Dossier
Registration Dossier
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EC number: 241-482-4 | CAS number: 17465-86-0
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Based on the assessment described in the subsections above the submission substance is not a PBT / vPvB substance.
- Likely routes of exposure:
The mean biodegradation of .alpha. -Cyclodextrin was 89% (ThODNH4); the 10 day window criterion was passed. The substance is non hazardous and did not show any negative effects on aquatic organisms in the acute tests (acute fish toxicity LC50 > 200 mg/L , acute daphnia toxicity EC50 >= 100 mg/L).
Also, the read-across test substance .beta.-cyclodextrin had no toxic effects on survival and reproduction of the Daphnia magna after an exposure period of 21 days up to the highest test concentration of 120 mg/L, therefore there is no evidence for long-term aquatic toxicity. The read-across approach was applicable due to the following reason: α-, ß-, and γ-Cyclodextrins consists of α-D-glucopyranoside units in a ring structure of 6, 7, or 8 units, respectively. Water solubility of these compounds will be found between 18 and 232 g/L at 25°C. The typical biodegradation route is a ring opening in the first step and then cleavage to oligo- or mono-saccharide units and further metabolisation to CO2.
The log Kow is -12.02 (calculated).
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