Registration Dossier
Registration Dossier
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EC number: 618-883-1 | CAS number: 92878-95-0
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 3-5 August 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 202 "Daphnia sp., Acute immobilisation Test"
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EC) No 440/2008 of 30 May 2008, Part C: Methods for the determination of ecotoxicity, Publication No. L142, C.2. "Daphnia Sp. Acute Immobilisation Test".
- Qualifier:
- according to guideline
- Guideline:
- other: ISO International Standard 6341: "Water quality - Determination of the inhibition of the mobility of Daphnia magna Straus - Acute toxicity test, Third edition, 1996-04-01.
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance document on aquatic toxicity testing of difficult substances and mixtures, OECD series on testing and assessment number 23, December 14, 2000.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- EC Number:
- 618-883-1
- Cas Number:
- 92878-95-0
- Molecular formula:
- C10H12ClNO4
- IUPAC Name:
- 2-(3-chloropropoxy)-1-methoxy-4-nitrobenzene
- Details on test material:
- The batch of WAY-188471 tested was a slightly yellow powder with a purity of 99.8% and not
completely soluble in test medium at the concentrations tested.
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- not specified
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 8.5 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 8.5 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 8.5 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study WAY-188471 did not induce acute immobilisation of Daphnia magna at 8.51 mg/l after 48 hours of exposure (NOEC).
The 48h-EC50 was beyond the range tested, i.e. exceeded an initial concentration of 8.5 mg/l.
Due to the very low solubility of WAY-188471 in water, concentration levels that might be toxic for Daphnia magna could not be reached.
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