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EC number: 500-295-0 | CAS number: 106233-09-4 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation (according to OECD 431 and 439; tiered testing strategy): not irritating to skin
Eye irritation (according to OECD 437, GLP): causes severe damage to eyes (Cat 1; H318)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
One vitro study on skin corrosion is available for Alcohols, C16-18, ethoxylated, phosphates (CAS 106233-09-4), which was performed according to OECD 431 (In vitro skin corrosion: human skin model test) and in compliance with GLP.
The test substance (20 mg) was applied to an intact reconstructed human epidermis (purchased as EPISKINTM) for 3, 60, and 240 min (each in duplicate cultures). After the incubation the skin surface was washed and the cell viability of the tissue was assessed by MTT reduction assay. A viability of 92.3, 79.5, and 67.9% was observed after the 3, 60, and 240 min exposure time, respectively. The negative and positive controls complied with the acceptance criteria. Therefore the test substance was considered as non-corrosive, as the viability was ≥35% (criteria for non-corrosivity).
Furthermore, an in vitro skin irritation study with Alcohols, C16-18, ethoxylated, phosphates (CAS 106233-09-4) is available, which was performed according to OECD 439 (in vitro skin irritation).
The test substance (10 mg) was applied to an intact reconstructed human epidermis (purchased as EPISKINTM) for 15 min (in triplicate cultures). After the incubation the skin surface was washed and the cell viability of the tissue was assessed by MTT reduction assay after a 42 h post-exposure period. A viability of 94.4% relative to the negative control was observed. The negative and positive controls complied with the acceptance criteria. Therefore the test substance was considered as non-irritant, as the viability was > 50%.
Eye irritation:
A study identifying ocular corrosives and severe irritants is available for Alcohols, C16-18, ethoxylated, phosphates (CAS 106233-09-4), which was performed according to OECD 437 (Bovine Corneal Opacity and Permeability Test Method) and in compliance with GLP.
The test substance was applied as a 20% solution on the cornea dissected from a cattle eye for 4 h (three corneas per group). After the incubation the epithelium was washed and the opacity and permeability was assessed. The corneas were retained after testing for possible conduct of histopathology. Macroscopic examination of the corneas revealed a clear, cloudy, and slightly cloudy appearance of the negative control, positive control, and the test substance group corneas, respectively. The In-vitro Irritancy Score (IVIS) was 4.6, 90.3, and 105.8 for the negative control, positive control, and the test substance group, respectively. Thus, the test substance was considered to be a severe irritant/corrosive (criteria for irritancy/corrosivity: IVIS ≥ 55.1).
Justification for selection of skin irritation / corrosion endpoint:
No selection was made as 2 key studies are available. A tiered testing strategy approach according to OECD 404 (adopted 2002) was applied.
Justification for selection of eye irritation endpoint:
Most reliable study. Equivalent to OECD guideline and in accordance with GLP.
Effects on eye irritation: corrosive
Justification for classification or non-classification
The available data on skin irritation of the test substance do not meet the criteria for classification according to regulation (EC) 1272/2008 and to Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
The available data on eye irritation of the test substance meet the criteria for classification as 'Causes serious eye damage: Cat 1' (H318) according to regulation (EC) 1272/2008 and as "Risk of serious damage to eyes" (R41) according to Directive 67/548/EEC.
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