Registration Dossier
Registration Dossier
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EC number: 229-662-0 | CAS number: 6642-31-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-03-24 - 1998-04-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 5.5 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 60 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- >= 7 - <= 7.4
- Remarks on result:
- other:
- Remarks:
- mean of determinations at 24, 48, and 72 h
- Water solubility:
- 5.52 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 60 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 7
- Water solubility:
- 5.46 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 60 g/L
- Incubation duration:
- 48 h
- Temp.:
- 20 °C
- pH:
- 7.1
- Water solubility:
- 5.46 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 60 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 7.4
- Conclusions:
- The water solubility of the substance was determined in a study similar to OECD 105, it was sufficiently documented and performed scientifically reasonable. Hence, the results can considered to be sufficiently reliable to asses the water solubility of the test item. The water solubility of the test substance has been determined to be 5.5 g/L at 20 °C and pH 7.2 (on average).
- Executive summary:
The water solubility of the substance was determined in a study similar to OECD 105, shake flask method, determination by HPLC. The water solubility of the test substance has been determined to be 5.5 g/L at 20 °C and pH 7.2 (on average).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 5.46 g/L
- Temp.:
- 20 °C
- pH:
- > 5.7 - < 6
Referenceopen allclose all
Description of key information
Water solubility:
- 5.5 g/l at 20°C, pH 7.0 – 7.4(flask method, OECD 105)
- 5.46 g/l at 20°C, pH 5.7 – 6.0 (flask method, OECD 105, GLP)
- 42 g/l at 25°C (QSAR estimation, database entry)
Key value for chemical safety assessment
- Water solubility:
- 5.46 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
