Registration Dossier
Registration Dossier
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EC number: 258-038-0 | CAS number: 52605-52-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The acute oral toxicity test of the given test material in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Prochlorperazine maleate
- EC Number:
- 201-511-3
- EC Name:
- Prochlorperazine maleate
- Cas Number:
- 84-02-6
- Molecular formula:
- C20H24ClN3S.2C4H4O4
- IUPAC Name:
- Prochlorperazine maleate
- Details on test material:
- - Name: Prochlorperazine maleate
- InChI: 1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
- Smiles: CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1.OC(=O)\C=C/C(=O)O.OC(=O)\C=C/C(=O)O
- Molecular formula:C28H32ClN3O8S
- Molecular weight :606.0928 g/mol
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 750 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 50% mortality was observed at 750 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 value was considered to be 750 mg/kg bw, when rats was treated with the given test chemical via oral route.
- Executive summary:
Acute oral toxicity study of the given test chemical was conducted in rats at the concentration of 750 mg/kg bw.
Animals were observed for mortality.50% mortality was observed at 750 mg/kg bw.
Hence, the LD50 value was considered to be 750 mg/kg bw, when rats was treated with the given test chemical via oral route.
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