Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 401-680-5 | CAS number: 125304-04-3 TINUVIN 171; TINUVIN 571
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OASIS Catalogic v5.14.1.5
2. MODEL (incl. version number)
CATALOGIC 301C v.11.16
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
7 representative structures of the UVCB
CCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O
CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(C)CCCCCCCCCC
CCCCCCC(CCCCC)c1cc(C)cc(N2Nc3ccccc3N2)c1O
CCCCCCC(CCCCC)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC
CCCCCCCCCCC(C)c1c(O)c(cc(C)c1C(CCCCC)CCCCCC)N2Nc3ccccc3N2
CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC
CCCCCCCCCCCCCCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
See attached QMRF.
5. APPLICABILITY DOMAIN
See attached QPRFs
6. ADEQUACY OF THE RESULT
- The model is scientifically valid (see attached QMRF).
- The model estimates the biodegradability of a substance and identifies its degradation metabolites.
- See attached QPRF for reliability assessment. - Principles of method if other than guideline:
- Estimation of ready biodegradation in water using CATALOGIC v5.14.1.5 BOD 28 days MITI (OECD 301C) v.11.16
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Model calculation
- Duration of test (contact time):
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 16
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- C12 linear: CCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 21
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- 2x C12 linear: CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(C)CCCCCCCCCC; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 2
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- C12 branched: CCCCCCC(CCCCC)c1cc(C)cc(N2Nc3ccccc3N2)c1O; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 3
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- 2x C12 branched: CCCCCCC(CCCCC)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 12
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- C12 linear, C12 branched: CCCCCCCCCCC(C)c1c(C(CCCCC)CCCCCC)c(C)cc(N2Nc3ccccc3N2)c1O; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 12
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- C12 branched, C12 linear: CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC; within parameter domain, out of structural fragment domain, within metabolic domain
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- QSAR model: based on OECD TG 301 C
- Value:
- 22
- Sampling time:
- 28 d
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Remarks:
- C24 linear: CCCCCCCCCCCCCCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O; within parameter domain, out of structural fragment domain, within metabolic domain
- Details on results:
- Structure 1, C12 linear:
CCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O
Predicted value (model result):
0.16 ± 0.0543
Concomitant predictions :
Not ready degradable
Primary Half Life = 1m 4d
Ultimate Half Life = 3m 19d
Structure 2, 2x C12 linear:
CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(C)CCCCCCCCCC
Predicted value (model result):
0.21 ± 0.0613
Concomitant predictions :
Not ready degradable
Primary Half Life = 18.65 days
Ultimate Half Life = 2m 22d
Structure 3, C12 branched:
CCCCCCC(CCCCC)c1cc(C)cc(N2Nc3ccccc3N2)c1O
Predicted value (model result):
0.02 ± 0.0146
Concomitant predictions :
Not ready degradable
Primary Half Life = 2m 30d
Ultimate Half Life = 2y 5m 29d
Structure 4, 2x C12 branched:
CCCCCCC(CCCCC)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC
Predicted value (model result):
0.03 ± 0.0183
Concomitant predictions :
Not ready degradable
Primary Half Life = 1m 22d
Ultimate Half Life = 2y 0m 30d
Structure 5, C12 linear – C12 branched:
CCCCCCCCCCC(C)c1c(O)c(cc(C)c1C(CCCCC)CCCCCC)N2Nc3ccccc3N2
Predicted value (model result):
0.12 ± 0.0356
Concomitant predictions :
Not ready degradable
Primary Half Life = 27.59 days
Ultimate Half Life = 5m 3d
Structure 6, C12 branched – C12 linear:
CCCCCCCCCCC(C)c1c(C)cc(N2Nc3ccccc3N2)c(O)c1C(CCCCC)CCCCCC
Predicted value (model result):
0.12 ± 0.0355
Concomitant predictions :
Not ready degradable
Primary Half Life = 27.59 days
Ultimate Half Life = 5m 3d
Structure 7, C24 linear:
CCCCCCCCCCCCCCCCCCCCCCC(C)c1cc(C)cc(N2Nc3ccccc3N2)c1O
Predicted value (model result):
0.22 ± 0.0753
Concomitant predictions :
Not ready degradable
Primary Half Life = 1m 4d
Ultimate Half Life = 2m 20d - Interpretation of results:
- not readily biodegradable
- Remarks:
- representative structures of UVCB
- Conclusions:
- The representative structures of the UVCB are not readily biodegradable. In total 126 metabolites (including the parents) at a quantity >=0.1% and a logKow of >4 could be identified.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985/11/22 - 20/12/1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, study was conducted under GLP like quality assurance.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- but GLP like quality assurance
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge:
Bacteria collected from activated sludge of the sewage treatment plant of CH-4153 Reinach on 19/11/85. The preparation was carried out according to the method described in the guideline. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:The test medium was prepared according to the method described in the guideline.
- Test temperature: 22 + or - 2 degrees
- Aeration of dilution water: Approx. 50 mL/min free of carbon dioxide.
TEST SYSTEM
- Culturing apparatus: 2 liters flasks equipped with gas inlet and magnetic stirrer.
- Number of culture flasks/concentration: 1
SAMPLING
- Sampling frequency: day 4 / 7 / 10 / 13 / 17 / 24 / 27 and 28 - Reference substance:
- aniline
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 13
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg/L test substance
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 19
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg/L test substance
- Details on results:
- The test item is not is not biodegradable in this test.
The biodegradation of the reference substances was calculated as 91 % in 28 days - Interpretation of results:
- other: not readily biodegradable
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1986-02-11
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, study was performed predated GLP.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: "Deutsche Einheitsverfahren zur Wasseruntersuchung" H 41 December 1980 DIN 38 409
- Principles of method if other than guideline:
- Determination of the chemical oxygen demand by oxydation of the test substance with potassium dichromate.
- GLP compliance:
- no
- Remarks:
- but GLP like quality assurance
- Oxygen conditions:
- other: not relevant
- Inoculum or test system:
- other: not applicable
- Duration of test (contact time):
- 2 h
- Details on study design:
- TEST CONDITIONS
- Test temperature: 148 +/- 3 degrees. - Reference substance:
- other: Potassium hydrogen phthalate
- Parameter:
- COD
- Value:
- 2.15 g O2/g test mat.
- Results with reference substance:
- Reference substance : 201 mg COD/L (limit: 192 - 208 mg COD/L)
Referenceopen allclose all
Result: 2.15 g O2/g test item
Description of key information
Not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
Additional information
According to the key study (CIBA, 1986) the ready biodegradability of the test item was assessed over a 28 day period by the modified Sturm test (OECD 301B). The nominal test concentrations were 10 and 20 mg a.s./L. The test material attained up to 13 and 19 % biodegradation after 28 days whereas the positive control substance (Aniline) was 94.4 % degraded 28 days. These results indicate that the test item cannot be classified readily biodegradable under conditions of the test.
In a supportive study (Ciba, 1986) the Chemical Oxygen Demand was determined. After an exposure of 2 h the amount of O2 was very low, indicating no degradation of the test item.
In addidition, ready biodegradtion in water was estimated by calculations with Oasis Catalogic v5.14.1.5 based on the model BOD 28 days MITI (OECD 301C) v.11.16. As a result, the representative structures of the UVCB are not readily biodegradable. In total 126 metabolites (including the parents) at a quantity >=0.1% and a logKow of >4 could be identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.