Registration Dossier
Registration Dossier
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EC number: 700-380-4 | CAS number: -
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: expert statement
- Adequacy of study:
- supporting study
- Reliability:
- other: not applicable
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of the dermal absorption potential of SymWhite 377.
Test material
- Reference substance name:
- 700-380-4
- EC Number:
- 700-380-4
- Molecular formula:
- A: C25H50O2 B: C27H54O2
- IUPAC Name:
- 700-380-4
- Reference substance name:
- Reaction mass of hexadecyl nonanoate and octadecyl nonanoate
- IUPAC Name:
- Reaction mass of hexadecyl nonanoate and octadecyl nonanoate
- Details on test material:
- - Name of test material: SymMollient S
- Molecular formula: A: C25H50O2; B: C27H54O2
- Molecular weight: A: 382.68 g/mol; B: 410.73 g/mol
- Flashpoint: 198.5 °C
- Self ignition temperature: 320 °C
- Melting point: 22 °C
- Boiling point: 412 - 417 °C
- Physical state: solid to liquid
No further information on the test material was stated.
Constituent 1
Constituent 2
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- SymMollient® S is intended to be used at a low application rate as a topical skin care product to regulate the moisture content of the skin by forming alight hydrophobic film on the skin that protects from drying out.
Based on the low water solubility (A: 3.5 µg/L/ B: 1.7 µg/L) and the high lipophilicity (logPow (calculated) = 11.2 / 12.2), quantitatively relevant dermal absorption cannot completely ruled out on the basis of theoretical considerations only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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