Registration Dossier
Registration Dossier
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EC number: 200-870-3 | CAS number: 75-44-5
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Manogue and Pigford
- Year:
- 1 960
- Bibliographic source:
- Phosgene, Robust Summaries, Submission to the US EPA HPV Challenge Program, July 2003.
Materials and methods
- Principles of method if other than guideline:
- Laboratory experimental procedures. Method not known.
Study on phosgene gas dissolved in aqueous solutions - GLP compliance:
- no
Test material
- Reference substance name:
- Phosgene
- EC Number:
- 200-870-3
- EC Name:
- Phosgene
- Cas Number:
- 75-44-5
- Molecular formula:
- CCl2O
- IUPAC Name:
- phosgene
Constituent 1
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- dioxomethane
- Inventory number:
- InventoryMultipleMappingImpl [inventoryEntryValue=EC 204-696-9]
- CAS number:
- 124-38-9
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- hydrochloric acid
Dissipation DT50 of parent compound
- Temp.:
- 25 °C
- DT50:
- 0 min
- Type:
- not specified
- Details on results:
- Phosgene dissolved in shore laminar jets of aqueous solutions decomposed rapidly. Rate
constants for hydrolysis to were estimated in a series of experiments in water and in sodium
nitrate and sodium hydroxide solutions at 25°C.
Estimated half-life of phosgene in water was approximately 0.026 seconds.
Phosgene hydrolyzed to carbon dioxide and hydrochloric acid in aqueous solutions.
The lack of stability of phosgene in water due to rapid hydrolysis is substantiated by other
laboratory studies on the gas phase hydrolysis of phosgene (Butler and Snelson, 1979).
Applicant's summary and conclusion
- Conclusions:
- Phosgene undergoes rapid hydrolysis in aqueous solutions. It is sparingly soluble in water and
reacts with water very rapidly. These characteristics make it difficult to accurately define water
solubility estimates and octanol-water partition coefficients. Modeled data (EPIWIN) for water
solubility and partition coefficients provide inaccurate estimates for these parameters because the
models do not take into account the rapid hydrolysis of phosgene in aqueous solutions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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