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EC number: 224-709-1 | CAS number: 4457-71-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was well conducted and described in accordance with GLP standards and according to an OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-methylpentane-1,5-diol
- EC Number:
- 224-709-1
- EC Name:
- 3-methylpentane-1,5-diol
- Cas Number:
- 4457-71-0
- Molecular formula:
- C6H14O2
- IUPAC Name:
- 3-methylpentane-1,5-diol
Constituent 1
- Specific details on test material used for the study:
- - Substance type: Colourless, clear liquid
- Physical state: liquid
- Analytical purity: 99.8%
- Impurities (identity and concentrations): 0.04% water; less than 0.02% CH3COOH.
- Lot/batch No.:WDK5014
- Stability under test conditions: stable (IR-tested)
- Storage condition of test material: stored in a refrigerator
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- A stock test solution was prepared by adding the test substance to dilution water (c= 10,000 mg/L).
From this stock solution, 4 actual test solutions (for 4 vessels) were prepared by further diluting the solution to 1,000 mg/L.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: US EPA Environmental research laboratory.
- Age at study initiation : immature
- Method of breeding: 2-4 week old, subcultured daphinas were used as parent for the immatures used in this test.
- Feeding during test:no
- Food type: unicellular algae
- Amount: 0.1 - 0.2 mg carbon/day/water flea.
- Frequency: daily during preparation phase. No feeding during test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 55.6
- Test temperature:
- 20°C +/- 1°C
- pH:
- 7.4 - 8.0
- Dissolved oxygen:
- 8.4 - 8.8 mg/L
- Nominal and measured concentrations:
- nominal: 1,000 mg/L.
measured:
start of test: 104% of nominal value
end of test: 101% of nominal value - Details on test conditions:
- TEST SYSTEM
- Test vessel: tall dish
- Type: open
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water from the city of Kurume
- Chlorine: was analyzed and observed to be lower than 0.02 mg/L
OTHER TEST CONDITIONS
- Adjustment of pH: no adjustment, but checking oh pH.
- Light intensity: Room light
TEST CONCENTRATIONS
- Test concentrations: 1,000 mg/L test solution
- Results used to determine the conditions for the definitive study: A 1,000 mg/L test solution was observed to have no harmful effects on daphnia in a preliminary study. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate; EiC50 = 0.283 mg/L after 48h.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
Any other information on results incl. tables
The total number of immobilized fleas in all test and control vessels was 0.
Applicant's summary and conclusion
- Conclusions:
- MPD was observed to cause no immobilizing effects on daphnia magnae after 48hrs at a concentration of 1,000 mg/L.
- Executive summary:
Toxic effects of MPD were tested towards Daphnia magna in a 48 -hour acute immobilization test. MPD was observed to have no immobilizing effects on Daphnia magna at a concentration of 1,000 mg/L. The NOEC and EiC50 are >1,000 mg/L.
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