Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-477-3 | CAS number: 26140-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In total, four study reports are available describing the effects of terphenyl mixtures on unicellular green algae, two of which are performed according to GLP principles. These two GLP studies on Santowax R (both K1) are the most recent algae studies and were performed without the use of a solvent to solubilize the test substance. The nominal concentrations were much higher than the solubilized fraction in those tests. The highest actual test concentration was 24.8 µg/l instead of the nominal concentration of 299 µg/l. No effects on growth rate were seen at this test concentration, thus the NOEC based on growth rate (72h) was above 24.8 µg/l. The NOEC for biomass in one of the tests was 3.22 µg/l (72h).
In the two other available studies (non-GLP) (K2), a solvent was used to improve the solubility of the substance (DMF or acetone). The actual concentrations were not measured in these studies and effects are thus expressed in nominal concentrations. The EC50 values (or ranges) are based on effects on biomass (96h) - not the REACH preferred endpoint - differed quite a lot between both studies (Therminol 88 (EC50 = 0.015 and 0.020 mg/L based on chlorophyl a and cell count respectively), Therminol 75 (EC50 = 0.103 mg/L based on cell count). This can be due to differences in composition between Therminol 88 and Therminol 75, but also differences in selected nominal concentrations (maximum conc of Therminol 88 was below the minimum conc of Therminol 75), or in solvent used.
The two studies on Santowax are clearly the most relevant and reliable studies since these are most recently performed according to the most recent guidelines. Additionally these studies assessed the appropriate REACH endpoint (growth rate, 72h) without using an additional solvent to improve the water solubility of the substance. Due to the fact that the other studies also provide valuable information, a Weight of Evidence approach was selected for these algae tests. For further risk assessment purposes, the test results from the study with Santowax R are selected. In this study the lowest NOEC value of 3.22 µg/l was reported.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.