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EC number: 246-129-8 | CAS number: 24292-60-2
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study conducted under GLP and according to ISO 13320:2009
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320:2009 and CIPAC MT 187
- GLP compliance:
- yes
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- other: laser diffraction
Test material
- Reference substance name:
- Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt
- EC Number:
- 246-129-8
- EC Name:
- Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt
- Cas Number:
- 24292-60-2
- Molecular formula:
- C21H28N7O17P3.2Na
- IUPAC Name:
- Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, disodium salt
- Details on test material:
- - Substance type: organic
- Physical state: white crystalline powder
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 33.01 µm
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- ca. 5.698 µm
- St. dev.:
- 0.085
- Percentile:
- D50
- Mean:
- ca. 25.621 µm
- St. dev.:
- 0.551
- Percentile:
- D90
- Mean:
- ca. 300.601 µm
- St. dev.:
- 5.905
Any other information on results incl. tables
Full Test Results
|
RUN 1 |
RUN 2 |
RUN 3 |
RUN 4 |
RUN 5 |
**Average |
|
Volume weighted Mean |
98.462 |
99.750 |
101.986 |
107.061 |
101.093 |
101.670 |
|
Median (d.50) |
26.142 |
26.204 |
24.739 |
25.774 |
25.293 |
25.621 |
|
Mode (µm) |
11.980 |
11.859 |
11.742 |
11.610 |
11.515 |
11.741 |
|
*MMAD |
33.681 |
33.761 |
31.874 |
33.208 |
32.588 |
33.010 |
|
10 % of material is < |
5.826 |
5.770 |
5.653 |
5.656 |
5.594 |
5.698 |
|
50 % of material is < |
26.142 |
26.204 |
24.739 |
25.774 |
25.293 |
25.621 |
|
90 % of material is < |
294.089 |
295.869 |
307.082 |
308.879 |
299.845 |
300.601 |
|
All results are in µm
* Mass Median Aerodynamic Diameter
** Average result is calculated from the entirety of data captured in each run and is not a
simple arithmetic mean.
23.99 % by volume of sample was seen to be < 10.00 µm.
Applicant's summary and conclusion
- Conclusions:
- Average (µm)
Volume weighted mean 101.670
Median (d.50) 25.621
Mode 11.741
MMAD (Mass Median Aerodynamic Diameter) 33.010
10 % of material is < 5.698
50 % of material is < 25.621
90 % of material is < 300.601 - Executive summary:
Both visual microscope and laser diffraction test were conducted to determine the particle size analysis of NADP,diNa powder. The study was conducted in accordance with ISO 13320:2009. For the full solubility and dispersability test, silicone oil was selected. The sample proved to be insoluble and well dispersed in silicone oil, therefore it was chosen as the suspension fluid.
The particle size was analysed over the range 0.02 Um to 2000 Um. The Mass Median Aerodynamic Diameter (MMAD) was 33.010 Um.
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