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Diss Factsheets
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EC number: 231-388-1 | CAS number: 7526-26-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 1.56 g/L
- Temp.:
- 20 °C
- pH:
- >= 5.4 - <= 5.5
- Remarks on result:
- other: Mean value of two determinations
- Details on results:
- Preliminary test
The preliminary estimate of water solubility was greater than 1.28 g/L at 20 °C.
Definitive test
Mean concentration: 1.56 g/L at 20.0 ± 0.5 °C (Samples 1 and 2)
Range: 1.53 to 1.59 g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the concentration range of 0 to 1.00 x 10^3 mg/L. This was satisfactory with a correlation coefficient (r^2) of 1.000 being obtained. - Conclusions:
- Interpretation of results: soluble (1000-10000 mg/L)
water solubility = 1.56 g/L at 20.0 ± 0.5 °C - Executive summary:
The water solubility of the test substance has been determined to be 1.56 g/L at 20.0 ± 0.5 °C by using the flask method in a GLP study (2012) according to OECD 105 and EU method A.6.
Reference
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Sample number | Time shaken at ~30 °C [h] | Time equilibrated at 20 °C [h] | Concentration [g/L] | Solution pH |
1 | 24 | 24 | 1.59 | 5.5 |
2 | 48 | 24 | 1.53 | 5.4 |
3 | 72 | 24 | 0.923* | 5.2 |
*Sample 3 not used in final result.
As the water solubility was determined during the preliminary test to be above 1x10-2 g/L, the flask shaking test was performed. The preliminary sample had no remaining visible excess test item after the equilibration period. Even so, the sample was analysed to determine if significant hydrolysis had occurred, this was not the case and gave a result of greater than 1.28 g/L. Therefore, it was decided to perform the definitive test at a loading rate of 10 g/L in expectation that the water solubility of the test item would not be significantly greater than 1.28 g/L. The preliminary test also indicated that as significant hydrolysis had not occurred, short term shaking periods for the definitive test were not required.
It is evident from the information obtained in the hydrolysis test (see IUCLID section 5.1.1) and data relating to the pH of the test item in water that negligible hydrolysis of the sample solution occurred during the course of the water solubility test.
The definitive result was calculated using Samples 1 and 2. For an unknown reason, Sample 3 was significantly lower than these and was therefore not included. As the preliminary result also indicated the water solubility was greater than 1.28 g/L, it was considered that not using Sample 3 was justified.
Description of key information
The water solubility of the test substance has been determined to be 1.56 g/L at 20.0 ± 0.5 °C by using the flask method in a GLP study (2012) according to OECD 105 and EU method A.6.
Key value for chemical safety assessment
- Water solubility:
- 1 560 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.