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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well performed and adequately described study with a complete test report, the only shortcoming is that the purity of the test substance was not specified
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
Principles of method if other than guideline:
-
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,7-trimethyloct-6-en-1-yn-3-ol
EC Number:
258-011-3
EC Name:
3,6,7-trimethyloct-6-en-1-yn-3-ol
Cas Number:
52567-96-1
Molecular formula:
C11H18O
IUPAC Name:
3,6,7-trimethyloct-6-en-1-yn-3-ol

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
4h
Observation period:
14 d
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 1.3
Max. score:
2
Reversibility:
fully reversible within: 14 d
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 1.3
Max. score:
2
Reversibility:
fully reversible within: 14 d
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 1.3
Max. score:
2
Reversibility:
fully reversible within: 14 d
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 7 d
Score:
ca. 0.7
Max. score:
1
Reversibility:
fully reversible within: 14 d
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 14 d
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
ca. 0.6
Max. score:
1
Reversibility:
fully reversible within: 14 d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 h
Score:
ca. 0.6
Max. score:
1
Reversibility:
fully reversible within: 14 d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
ca. 1
Max. score:
2
Reversibility:
fully reversible within: 14 d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 7 d
Score:
ca. 0.3
Max. score:
1
Reversibility:
fully reversible within: 14 d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 14 d
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 14 d
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
ca. 1
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24 h
Score:
ca. 2
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24 h
Score:
ca. 1
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
48 h
Score:
ca. 2
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
48 h
Score:
ca. 2
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
48 h
Score:
ca. 0
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
72 h
Score:
ca. 2
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
72 h
Score:
ca. 2
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
72 h
Score:
ca. 0
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
ca. 1
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
ca. 1
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
ca. 0
Other effects:
-

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
It is considered that the test article, Methyl Dehydrolinalool, is a slight irritant
to rabbit skin under the conditions of this study.
Executive summary:

The purpose of this study was to assess the degree of irritation produced by the test article, Methyl Dehydrolinalool, when applied to the intact skin of the albino rabbit. The procedures used meet the requirements of OECD Guideline No. 404, adopted 17th July 1992. A 0.5ml aliquot of the test article was applied over a previously clipped area of the dorsal skin of each of 3 albino rabbits. The test article was held in contact with the skin, under a semiocclusive patch assembly, for a 4 hour period. The patch was then removed and the treated site gently cleansed with water. Skin reaction, i.e. erythema and eschar as well as oedema formation, was assessed 1, 24, 48 and 72 hours after patch removal. Additional assessments of skin reaction were made 7 and 14 days after dosing. Treatment with the test article produced a skin reaction characterised by very slight to well defined erythema in all 3 animals and in 2 animals barely perceptible or slight oedema. This response persisted in 2 animals 72 hours after patch removal. Seven days after dosing, very slight erythema was still apparent in these animals and was accompanied in one rabbit by very slight oedema. By the end of the 15 day observation period, the skin over the treated site on all 3 rabbits had a normal appearance. The primary irritation index was calculated to be 2.2 It is considered that the test article, Methyl Dehydrolinalool, is a slight irritant to rabbit skin under the conditions of this study.