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EC number: 274-386-6 | CAS number: 70209-87-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 April 2014 to 04 September 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC-column
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- HPLC-system:
Agilent Technologies 1260 Infinity
Quaternary pump G1311B
Autosampler ALS G1367E
Column oven G1316A
Detector DAD G4212B
Column specification: EC 150/4.6 Nucleodur 100-5 CN-RP 150 x 5
Column temperature: 25 °C
Detection wavelength standard solutions: 220 nm
Detection wavelength test item: 220 nm
Mobile phase: Methanol/water (55/45,v/v)
Flow rate: 0.5 mL/min
Injection volume: 2 µL (reference items); 2 µL (test item) - Key result
- Type:
- log Koc
- Value:
- < 1.5
- Temp.:
- 25 °C
- Details on results (HPLC method):
- The aim of this study was the determination of the adsorption coefficient of the test item FAT 20060/F by high performance liquid chromatography (HPLC) method according to EC method C.19 and OECD guideline 121. The analysis was performed on an analytical column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties. A moderately polar stationary phase based on a silica matrix was used (Nucleodur 100-5 CN-RP). A 55/45 (v/v) methanol/ water mixture was used as mobile phase and the column temperature was 25 °C. FAT 20060/F eluted with a retention time of 1.82 min. Since this retention time is lower than the determined dead time of the HPLC, the adsorption coefficient could not be calculated and is therefore below the determination limit of the method (<1.5).
- Validity criteria fulfilled:
- yes
- Conclusions:
- FAT 20060/F eluted with a retention time of 1.82 min. Since this retention time is lower than the determined dead time of the HPLC, the adsorption coefficient could not be calculated and is therefore below the determination limit of the method.
- Executive summary:
The aim of this study was the determination of the adsorption coefficient of the test item FAT 20060/F by high performance liquid chromatography (HPLC) method according to EC method C.19 and OECD guideline 121. The analysis was performed on an analytical column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties. A moderately polar stationary phase based on a silica matrix was used (Nucleodur 100-5 CN-RP). A 55/45 (v/v) methanol/water mixture was used as mobile phase and the column temperature was 25 °C. FAT 20060/F eluted with a retention time of 1.82 min. Since this retention time is lower than the determined dead time of the HPLC, the adsorption coefficient could not be calculated and is therefore below the determination limit of the method. The results are listed below:
Peak No.
Mean retention time of two runs
[min]
Absolute deviation
[min]
Mean log Kocof two runs
1
1.82
0.00
<1.5*
*: below determination limit of the method
Reference
None
Description of key information
FAT 20060/F eluated with a retention time of 1.82 min. Since this retention time is lower than the determined dead time of the HPLC, the adsorption coefficient could not be calculated and is therefore below the determination limit of the method.
Key value for chemical safety assessment
- Koc at 20 °C:
- 31.6
Additional information
The aim of this study was the determination of the adsorption coefficient of the test item FAT 20060/F by high performance liquid chromatography (HPLC) method according to EC method C.19 and OECD guideline 121.The analysis was performed on an analytical columnpacked with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties. A moderately polar stationary phase based on a silica matrix was used (Nucleodur 100-5 CN-RP). A 55/45 (v/v) methanol/water mixture was used as mobile phase and the column temperature was 25 °C. FAT 20060/F eluted with a retention time of 1.82 min. Since this retention time is lower than the determined dead time of the HPLC, the adsorption coefficient could not be calculated and is therefore below the determination limit of the method. The results are listed below:
Peak No. | Mean retention time of two runs [min] | Absolute deviation [min] | Mean log Koc of two runs |
1 | 1.82 | 0.00 | <1.5* |
*: below determination limit of the method
[LogKoc: 1.5]
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