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EC number: 237-253-3 | CAS number: 13709-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- There is no guideline available for this route of administration. However the study was conducted in accordance with sound scientific principles and was reported in sufficient detail to assess the scientific merit of the results.
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Neodymium trifluoride
- EC Number:
- 237-253-3
- EC Name:
- Neodymium trifluoride
- Cas Number:
- 13709-42-7
- Molecular formula:
- F3Nd
- IUPAC Name:
- neodymium trifluoride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Appearance: pink powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Sprague-Dawley OFA (IOPS)
- Age at study initiation: 6 - 7 weeks
- Weight at study initiation (prior to fasting): 160 - 200 g (males); 140 - 180 g (females)
- Fasting period before study: yes (17 - 19 hours)
- Housing: 2 or 5 animals in plastic cages (365 x 225 x 180 mm) containing a sterilised and vacuum-cleaned sawdust litter
- Food consumption: ad libitum
- Water consumption: ad libitum
- Acclimation period: data not available
ENVIRONMENTAL CONDITIONS:
- Temperature: 22 ± 1.5 °C
- Humidity: 55 ± 15 %
- Air changes: 10 per hour
- Photoperiod: data not available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: 10 % aqueous dispersion of gum arabic
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 50 g test item / 100 mL
- Amount of vehicle: 10 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 0 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose.
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> behaviour and mortality: 1 h, 2 h, 4 h, and on days 1, 2, 4, 7 and 14 after treatment
> weighing: one day before treatment, and on days 0, 7 and 14 after treatment
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality seen.
- Clinical signs:
- Some animals were observed to have hollow flanks, while others were observed to have bloated bellies. These observations are summarised in Table 1.
- Body weight:
- No abnormal effects on bodyweight were reported.
- Gross pathology:
- Postmortem examinations were performed after sacrifice at the end of the observation period. The abdominal and chest cavities were opened and the organs inspected.
During these examinations, it was noted that the test material was present with granulomas. - Other findings:
- No mortality observed in the preliminary study.
Any other information on results incl. tables
Table 1: Summary of Observations
Dose (mg/kg) |
Observation |
Number of Animals |
Cumulative Mortality |
|||||||||||||||||
Hours |
Days |
|||||||||||||||||||
0.25 |
1 |
2 |
4 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
|||
5000 |
Hollow flanks |
- |
- |
- |
- |
- |
5 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
0/10 |
Bloated belly |
- |
- |
- |
- |
- |
5 |
3 |
3 |
3 |
3 |
2 |
2 |
2 |
2 |
2 |
2 |
- |
1 |
||
Mortality |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the LD0 of the test material to the Sprague-Dawley rat is >5000 mg/kg when administered via the intraperitoneal route in a 10 % aqueous dispersion of gum arabic.
- Executive summary:
The acute toxicity of the test material was investigated via the intraperitoneal route. No guideline was available for this type of study, however it was carried out in accordance with sound scientific methodology and the principles of good laboratory practice.
10 fasted Sprague-Dawley rats (5 per sex) were administered the test material via the intraperitoneal route in a 10 % aqueous dispersion of gum arabic. The animals were observed for 14 days before being euthanised and subject to necropsy.
There was no mortality seen and no abnormal effects on bodyweight were reported. Clinical signs observed were hollow flanks in some animals, while others were observed to have bloated bellies.
During the postmortem examinations, the abdominal and chest cavities were opened and the organs inspected. It was noted that the test material was present with granulomas.
Under the conditions of this study, the LD0 of the test material to the Sprague-Dawley rat is >5000 mg/kg when administered via the intraperitoneal route in a 10 % aqueous dispersion of gum arabic.
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