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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP and non-guideline compliant

Data source

Reference
Reference Type:
publication
Title:
Acute inhalation toxicology and proposed emergency exposure limits of nitrogen trifluoride
Author:
Vernot, E. H., Haun, C. C. MacEwen, J. D. & Egan, G. F.
Year:
1973
Bibliographic source:
Toxicology and applied pharamacology, 26, pp 1-13

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study involved exposing several species of animal in NF3 for various times in order to determine LC50 values for 15, 30 and 60 mins
GLP compliance:
no
Test type:
fixed concentration procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrogen trifluoride
EC Number:
232-007-1
EC Name:
Nitrogen trifluoride
Cas Number:
7783-54-2
Molecular formula:
F3N
IUPAC Name:
trifluoroamine
Test material form:
gas

Test animals

Species:
other: rat ,mice, monkey, dog
Strain:
other: SD, ICR, rhesus, beagle

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Male SD and ICR mice were exposed (whole body) in a 30L bell jar chamber (10/gp of the same species). NF3 was introduced into the air stream prior to entry into a duplicate chamber which was used to establish contaminant concentrations. Air flow was fixed at 30 L/minute.
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
ca. 15 - ca. 60 min
Concentrations:
Refer to results section
No. of animals per sex per dose:
10/gp
Control animals:
no
Details on study design:
Animals surviving the exposure were held up to 2 weeks to include delayed deaths. 
Statistics:
LC50 calculations were made by computerised version of the probit method of Finney.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 6 700 ppm
95% CL:
ca. 6 130 - ca. 7 320
Exp. duration:
60 min
Remarks on result:
other: rat
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 3 350 ppm
Based on:
other: time adjusted
Exp. duration:
4 h
Remarks on result:
other: rat
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 7 500 ppm
95% CL:
ca. 6 800 - ca. 8 280
Exp. duration:
60 min
Remarks on result:
other: mouse
Sex:
male
Dose descriptor:
LC50
Effect level:
ca. 3 700 ppm
Based on:
other: time adjusted
Exp. duration:
4 h
Remarks on result:
other: mouse

Any other information on results incl. tables

Table 7.2.2/01-1: Mortality in rats and mice exposed to NF3 for 60 minutes

Concentration (ppm)

Mortality

Mean

Range

RAT

4118

4018 – 4428

0/10

5117

5002 – 5298

1/10

6121

5986 – 6232

4/10

7190

7134 – 7257

5/10

8204

8036 – 8282

9/10

LC50: 6700 ppm (6130 – 7320)

MOUSE

4112

3854 - 4264

0/10

6469

6297 – 6560

3/10

7150

6888 – 7544

4/10

8200

8150 – 8250

6/10

12218

12136 – 12300

10/10

LC50: 7500 ppm (6800 – 8280)

 

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria