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EC number: 223-772-2 | CAS number: 4065-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment - Test material
- Author:
- COSMETIC INGREDIENT REVIEW
- Year:
- 1 983
- Bibliographic source:
- Journal of the American College of Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- To evaluate mutagenic effects of the given test chemical by the Ames Salmonella /Mammalian-Microsomal Assay.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sulisobenzone
- EC Number:
- 223-772-2
- EC Name:
- Sulisobenzone
- Cas Number:
- 4065-45-6
- Molecular formula:
- C14H12O6S
- IUPAC Name:
- 5-benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Benzophenones-4
- Molecular formula- C14H12O6S
- Molecular weight: 308.3088 g/mole
- Substance type:Organic
- Physical state: pale ivory-colored powder
- Purity: 99% (lab-grade)
- Impurities (identity and concentrations): No data available.
- InChI: 1S/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)
- Smiles: c1(cc(c(cc1O)OC)S(=O)(=O)O)C(=O)c1ccccc1
Constituent 1
Method
- Target gene:
- Histidine
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98, TA100, TA1535, TA1537, and TA1538
- Details on mammalian cell type (if applicable):
- No data
- Additional strain / cell type characteristics:
- not applicable
- Cytokinesis block (if used):
- No data
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor-induced rat liver microsomal S-9 cell fraction
- Test concentrations with justification for top dose:
- 1.0 - 1000 µg/plate
- Vehicle / solvent:
- Vehicle(s)/solvent(s) used: DMSO
Justification for choice of solvent/vehicle: The chemical is soluble in DMSO.
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- True negative controls:
- not specified
- Positive controls:
- not specified
- Details on test system and experimental conditions:
- No data
- Rationale for test conditions:
- No data
- Evaluation criteria:
- No data
- Statistics:
- No data
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA98, TAl00, TA1535, TA1537, and TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Positive controls validity:
- not specified
- Additional information on results:
- RANGE-FINDING/SCREENING STUDIES: Preliminary cytotoxicity studies determined the dose range of the compound to be used.
- Remarks on result:
- other: No mutagenic potential
Applicant's summary and conclusion
- Conclusions:
- The test chemical tested negative for mutagenicity in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 in the presence and absence of S9 activation system.
- Executive summary:
The chemical was tested for mutagenicity in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 at multiple doses ranging from 1 to 1000 µg/plate, with and without Aroclor-induced rat liver microsomal S9 cell fraction. Dose levels were selected based on preliminary cytotoxicity studies. The results in the main study were evaluated against solvent control data. The test chemical was conclusively non-mutagenic in all strains with and without metabolic activation up to 1000 µg/plate. It was not specified whether positive controls were included or not, however, a number of other chemicals that were investigated in the study tested positive for mutagenicity in the presence, but not in the absence, of the metabolic activation system. This indicates that the metabolic activation system was functioning.
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