Registration Dossier
Registration Dossier
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EC number: 700-651-7 | CAS number: 692-49-9
Endpoint summary
Administrative data
Description of key information
Inhalation: OECD 403; rat 4-hr LC50 >102900 ppm (>690413 mg/m3). Reliability =2
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 690 413 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an OECD 403 guideline study conducted under GLP conditions, one group of 5 male and 5 female Crl:CD(SD) albino rats were exposed nose-only to vapours of the substance for 4 hours at a concentration of 102900 ppm, the highest achievable vapour concentration. No mortality or significant clinical signs were observed during the exposure or the 14-day post-exposure observation period. There were no remarkable changes in body weight. Under the conditions of this study, the 4-hour LC50 in rats was greater than 102900 ppm (690413 mg/m3).
In another GLP acute (approximate lethal concentration (ALC)) inhalation toxicity study, one group of 4 male Crl:CD(SD) rats were exposed whole-body for a single, 2-hour period to vapours of substance at 21000 ppm. No mortality was observed during the exposure or the 14-day recovery period. Irregular respiration was observed during exposure as well as a slight body weight loss (0.31% - 4.6%) on the day after exposure, followed by normal weight gain for the remainder of the recovery period. Under the conditions of this study, the 2-hour ALC in rats was greater than 21000 ppm (140902 mg/m3).
Justification for selection of acute toxicity – inhalation
endpoint
OECD guideline, GLP study
Justification for classification or non-classification
Based on the inhalation 4-hour LC50 in rats of >102900 ppm (690419 mg/m3), no classification is required for acute inhalation endpoint according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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