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EC number: 268-440-8 | CAS number: 68084-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-01-08 to 2019-03-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- deviations do net effect the integrity of the study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- 3 vessels (test item), 2 method blanks were set up in a parallel design, each vessel was sampled several times/ Test under argon, exclusion of O2 and CO2 / Homogenisation of the test item (2nd test)/ Max. temp. was not always 20.0±1.0°C (21.3°C, 2nd test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2015-12-16
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Storage condition of test material: Room temperature, closed
- Treatment of test material prior to second testing:
It was decided to homogenise the test item by heating up slowly to 85 °C in a water bath and carefully stirring manually with a PTFE spatula. As the test item became more fluid heating up to 85 °C was considered to be sufficient for sampling. Sample aliquots were weighed into test vessels (3 replicates) and a second main test was started. This is not critical and has no influence on the validity and quality of the study because heating up the test item to 85 °C allows to take a sample that is representative for the test item. Hence, test results should be more precise. - Water solubility:
- 29.9 µg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Cerium
- Loading of aqueous phase:
- 50 other: mg test item / L
- Incubation duration:
- >= 1 - <= 17 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7
- Remarks on result:
- other: S.D.: ± 14.1 μg Ce/L
- Key result
- Water solubility:
- 157.5 µg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 50 mg/L
- Incubation duration:
- >= 1 - <= 17 d
- Temp.:
- 20 °C
- pH:
- >= 6.1 - <= 7
- Remarks on result:
- other: S.D.: ± 74.4 μg/L
- Remarks:
- water solubility of the test item was calculated based on a cerium content of 19 % and a dissolved cerium amount of 29.9 ± 14.1 μg/L.
- Details on results:
- Temperature:
- The mean temperature in the preliminary test was 20.2 ± 0.1 °C. The recorded minimum temperature was 20.1 °C and the maximum was 20.8 °C.
- The mean temperatures in the 1st main test after test start were 20.3 ± 0.1 °C and 20.1 ± 0.1 °C. The minimum temperature was 19.8 °C and the maximum was 21.0 °C.
- The mean temperatures in the 2nd main test after test start were 20.1 ± 0.2 °C and 19.8 ± 0.2 °C. The minimum temperature was 19.7 °C and the maximum was 21.3 °C.
Measured solution pH:
- In the 1st test the pH of solutions containing the test item were in the range of 5.4 – 6.6, whereas the pH of method blanks were in the range of 5.7 - 7.6.
- In the 2nd test the pH of solutions containing the test item were in the range of 6.1 – 7.0, whereas the pH of method blanks were in the range of 6.1 - 7.3.
Oxygen concentration:
- The oxygen concentration was measured throughout the preliminary test, pre saturation phases and during the main tests at 20.0 ± 1.0 °C. The measured O2 concentrations were always below 1.6 % and around 0 %.
Turbidity:
- The turbidity in samples from main tests was always < 1 NTU indicating that filtered solutions did not contain any undissolved material immediately after filtering. - Conclusions:
- Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 50.1, 51.4 and 51.5 mg/L test substance for three replicates, respectively), a solubility equilibrium was reached. The mean of dissolved cerium concentrations (< 0.22 μm) measured on day 1, 2, 3 and 15, 16 and 17 at 20.0 ± 1.0 °C amounts to 29.9 ± 14.1 μg/L corresponding to a water solubility of 157.5 ± 74.4 μg/L test item based on a cerium content of 19 %. The pH of solutions containing the test item remained in the range of 6.1 – 7.0 whereas the pH of method blanks ranged from 6.1 - 7.3 during the main test.
Reference
ICP-OES measurement series (on January 25, 2019) - preliminary test.
Calibration [µg/L] – lowest and highest calibration point |
Chosen wavelength [nm] |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
1.0 – 1000 (total of 13 calibration points, 12 used + blank) |
456.236 |
Ce: 1.45 |
Ce: |
Ce: 1.000 |
Ce: 9 |
Ce: 100 |
Recovery/validation data cerium of measurement series on January 25, 2019 (preliminary test)
Element Ce |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
Recalibration 25 µg/L |
107 |
1 |
2 |
2 |
LabKings + Ce 50 µg/L |
102 |
1 |
2 |
2 |
Recalibration 250 µg/L |
101 |
<1 |
2 |
2 |
LabKings + Ce 500 µg/L |
100 |
1 |
2 |
2 |
Fortification of measurement series on January 25, 2019 (preliminary test)
Sample |
Element |
Measured concentration [µg/L] |
Calculated level after addition [µg/L] |
Recovery |
19Y0085: Sample a from test vessel in preliminary test, (dilution 10-fold) – 1 mL sample and 4 mL 250 µg/L standard |
Ce |
117 |
223 |
223 / 99.7 # |
# Internal calculations were performed with more digits.
ICP-MS measurement series
Calibration [µg/L] – lowest and highest calibration point |
Chosen isotope |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery of quality assurance samples [%] |
January 25, 2019; measurement of test samples and method blanks from 1st test (days 1, 2, 3) |
||||||
1.0 – 100 (total of 11 calibration points, 11 used + blank) |
140Ce in high helium mode |
Ce: 0.0021 |
Ce: 0.0064 |
Ce: 0.9998 |
Ce: 19 |
Ce: 100 |
March 08, 2019; measurement of test samples and method blanks from 2nd test (days 1, 2, 3) |
||||||
0.100 – 250 (total of 14 calibration points, 14 used + blank) |
142Ce in high helium mode |
Ce: 0.0020 |
Ce: 0.0061 |
Ce: 1.000 |
Ce: 33 |
Ce: 100 |
March 22, 2019; measurement of test samples and method blanks from 2nd test (days 15, 16, 17) |
||||||
0.250 – 500 (total of 14 calibration points, 14 used + blank) |
14ßCe in helium mode |
Ce: 0.0003 |
Ce: 0.0009 |
Ce: 1.000 |
Ce: 33 |
Ce: 97.0 |
Recovery/validation data cerium of measurement series
Element Ce |
Recovery [%] |
SD [%] |
n (total) |
n (valid) |
January 25, 2019 (1st test) |
||||
Recalibration 2 µg/L |
99.1 |
0.3 |
4 |
4 |
LabKings + Ce 7.5 µg/L |
98.7 |
0.4 |
4 |
4 |
Recalibration 20 µg/L |
98.2 |
0.8 |
4 |
4 |
LabKings + Ce 75 µg/L |
100 |
<1 |
4 |
4 |
March 08, 2019 (2nd test) |
||||
LabKings + Ce 0.75 µg/L |
94.7 |
1.9 |
6 |
6 |
Recalibration 10 µg/L |
104 |
2 |
6 |
6 |
LabKings + Ce 7.5 µg/L |
94.0 |
0.6 |
6 |
6 |
Recalibration 100 µg/L |
104 |
1 |
6 |
6 |
LabKings + Ce 75 µg/L |
96.6 |
1.5 |
6 |
6 |
March 22, 2019 (2nd test) |
||||
LabKings + Ce 2.5 µg/L |
98.8 |
0.8 |
6 |
6 |
Recalibration 10 µg/L |
100 |
1 |
6 |
6 |
LabKings + Ce 25 µg/L |
106# |
10# |
6# |
5# |
Recalibration 100 µg/L |
107 |
3 |
6 |
6 |
LabKings + Ce 250 µg/L |
105 |
3 |
6 |
6 |
# Recovery of one sample is 125 %. This is not critical because 97.0 % of all QA/QC samples are within the limits of 100 ± 15 %.
Fortification of measurement series
Sample |
Element |
Measured |
Calculated level |
Recovery |
January 25, 2019 (1st test) |
||||
19Y0181: Vessel 3 sample a 1d – 1 mL sample and 4 mL 60 µg/L standard |
Ce |
0.339 |
48.1 |
49.5 / 103 |
19Y0199: Vessel 4 sample a 2d – 1 mL sample and 4 mL 80 µg/L standard |
Ce |
37.6 |
71.5 |
72.7 / 102 |
19Y0217: Vessel 5 sample a 3d – 1 mL sample and 4 mL 40 µg/L standard |
Ce |
29.5 |
37.9 |
37.4 / 98.7 |
March 08, 2019 (2nd test) |
||||
19Y0671: Vessel 4 sample a 1d – 1 mL sample and 4 mL 25 µg/L standard |
Ce |
45.9 |
29.2 |
29.0 / 99.4 |
19Y0689: Vessel 5 sample a 2d – 1 mL sample and, 4 mL 50 µg/L standard |
Ce |
24.2 |
44.8 |
44.9 / 100 |
19Y0703: Vessel 4 sample a 3d – 1 mL sample and 4 mL 10 µg/L standard |
Ce |
57.7 |
19.5 |
19.4 / 99.1 |
March 22, 2019 (2nd test) |
||||
19Y0749: Vessel 4 sample a 15d – 1 mL sample and 4 mL 50 µg/L standard |
Ce |
35.3 |
47.1 |
50.6 / 107 |
19Y0763: Vessel 3 sample a 16d – 1 mL sample and, 4 mL 75 µg/L standard |
Ce |
16.6 |
63.3 |
67.6 / 107 |
19Y0783: Vessel 5 sample a 17d – 1 mL sample and 4 mL 100 µg/L standard |
Ce |
11.1 |
82.2 |
85.9 / 104 |
Preliminary test:
Cerium concentrations were measured by ICP-OES. The mean measured dissolved Ce concentration was 1.17 ± <0.01 mg/L corresponding to 6.16 ± 0.01 mg/L test item (calculated based on Ce content of 19 %). According to the guideline at least five times the amount needed for a solubility equilibrium (observed in preliminary test) has to be applied in the main test.
1st test
Cerium concentrations in the range of 0.074 – 47.4 μg Ce /L were measured. Since the cerium concentration of replicate solutions differed by more than two magnitudes, it was decided to terminate the 1st test after 3 days and to start a 2nd test.
2nd test
Background cerium levels of method blanks were below the respective LOD and/or LOQ during the test. Measured dissolved cerium concentrations remained with a mean of about 40 μg Ce/L relatively constant on day 1, 2 and 3. However, in order to exclude that the concentrations would increase with time, the test was extended for 2 weeks. Measured dissolved cerium concentrations on day 15, 16 and 17 with a mean of 20 μg Ce/L were significantly lower than concentrations measured on day 1, 2 and 3. Thus, a decrease of dissolved Ce concentrations was observed during the test which may be explained with a slow Ce precipitation or reprecipitation of the solubilized test material.
Thus, the mean of Ce concentrations measured on day 1, 2, 3 and 15, 16 and 17 was used to estimate the water solubility of cerium neodecanoate, representative for the 17-day test.
Since, “the concentrations measured in at least the two last vessels [i.e. the concentrations measured on the last two sampling days] do not differ by more than 15%” and concentrations measured on the last two sampling days do not increase, the validity criteria of OECD 105 and Regulation 440/2008/EC A.6 are fulfilled.
The estimated water solubility of the test substance is based on mean dissolved cerium concentrations of all sampling days (1, 2, 3, 15, 16, 17) as follows:
1. Replicate: 27.2 ± 9.1 μg Ce /L
2. Replicate: 42.8 ± 11.9 μg Ce /L
3. Replicate: 19.7 ± 10.4 μg Ce /L
Mean: 29.9 ± 14.1 μg Ce /L
Based on the properties of the test item (UVCB substance, 19% cerium content), the water solubility of the test substance is calculated as follows:
Mean of concentration x 100 % / 19 %:
1. Replicate: 143.3 ± 48.0 μg/L test item
2. Replicate: 225.5 ± 62.4 μg/L test item
3. Replicate: 103.9 ± 54.7 μg/L test item
Mean: 157.5 ± 74.4 μg/L test item
Description of key information
Cerium neodecanoate has a water solubility of 157.5 ± 74.4 μg/L at 20.0 ± 1.0 °C and pH 6.1 -7.0.
Key value for chemical safety assessment
- Water solubility:
- 157.5 µg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of this test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 50.1, 51.4 and 51.5 mg/L test substance for three replicates, respectively), a solubility equilibrium was reached. The mean of dissolved cerium concentrations (< 0.22 μm) measured on day 1, 2, 3 and 15, 16 and 17 at 20.0 ± 1.0 °C amounts to 29.9 ± 14.1 μg/L corresponding to a water solubility of 157.5 ± 74.4 μg/L test item based on a cerium content of 19 %. The pH of solutions containing the test item remained in the range of 6.1 – 7.0 whereas the pH of method blanks ranged from 6.1 - 7.3 during the main test.
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