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EC number: 221-493-0 | CAS number: 3119-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Jan 2002 and 19 Feb 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 3-amino-2,4,6-triiodobenzoic acid
- EC Number:
- 221-493-0
- EC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Cas Number:
- 3119-15-1
- Molecular formula:
- C7H4I3NO2
- IUPAC Name:
- 3-amino-2,4,6-triiodobenzoic acid
- Test material form:
- solid: bulk
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- > 0.435 - < 0.453 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 0.01 g/L
- Incubation duration:
- < 7 d
- Temp.:
- 20 °C
- pH:
- ca. 3.13
- Remarks on result:
- other: standard deviation
- Remarks:
- 0.008 g/L
Any other information on results incl. tables
The water solubility of the test item was determined using the flask method which is based on a suspending of the test substance in the solvent until saturation is reached, followed by separation of the saturated solution from the insoluble residues. The concentration was monitored by HPLC analysis. The results are given in the following table:
Table 1: Water solubility of the test item
t (days) |
S 20°C (g/L) experiment A |
S 20°C (g/L) experiment B |
3 |
0.4975* |
0.4782* |
4 |
0.4445 |
0.4272 |
6 |
0.4471 |
0.4483 |
7 |
0.4474 |
0.4488 |
t: sampling time, time from start of the experiment at 20°C
S20°C-exp.A / S20°C-exp.B: raw data of the experiment A and B (duplicate)
* equilibrium not reached, therefore not taken for the calculation of the mean value
Averaging the actual concentrations of series of experiments after equilibration gives the following solubility of the test item with 95 % confidence interval:S20°C = 0.444 g/L ± 0.009 g/L.
Standard deviation: s = 0.008 g/L
The pH value of the aqueous solution was determined to be 3.13.
The investigation of the insoluble residue by HPLC showed no increase of decomposition products. According to X-ray powder diffraction the starting material and the insoluble residue consist of the same solid state form (see attatchment).
Applicant's summary and conclusion
- Conclusions:
- The mean measured water solubility of the test substance by HPLC was S20°C = 0.444 g/L ± 0.009 g/L (pH = 3.13).
- Executive summary:
The water solubility of the test item was determined using the flask method. The following solubility with 95 % confidence interval of the substance in saturated solution was obtained after equilibration at 20°C and separation from the insoluble residues : S20°C = 0.444 g/L ± 0.009 g/L.The pH value of the aqueous solution was determined to be 3.13. The test item can be considered as very slightly soluble in accordance with the descriptive term of Ph.Eur., 3rd Edition and USP 24. According X-ray powder diffraction the starting material (batch 60708021) consist of the same solid state form as the insoluble residue.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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