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EC number: 217-210-5 | CAS number: 1777-82-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A total of 94.9 % of the dose (88.4 % urine, 3.7 % faeces and 2.9 % at site of application and in the carcass) was recovered over a period of 96 h after occlusive dermal application of the [14C]-test substance to rats. Four metabolites were detected and excretion mainly occurred via urine.
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 94.9
Additional information
Dermal absorption, distribution, metabolism and excretion
The percutaneous absorption and disposition of the test substance (labelled with carbon-14) has been studied in the rat. Preliminary experiments showed that [14C]-test substance was absorbed to a greater extent from an acetone solvent than from either acetone:water (90:10 v/v) or water alone. Absorption and excretion of radioactivity was rapid after a single occlusive cutaneous dose of [14C]-test substance (1.0 mg/kg bw) given as an acetone solution. A total of 94.9 % of the dose (88.4 % urine, 3.7% faeces and 2.9 % at site of application and in the carcass) was recovered over a period of 96 h after occlusive application of the dose. The large majority of this (85.4 %) being excreted in the first 24 h period. No radioactivity was detected in expired air during the 96 h period. Twelve hours after cutaneous application of [14C]-test substance (1.0 mg/kg bw) the highest tissue concentrations of radioactivity were found in liver, kidney, stomach, and urino-genital system. At 24 and 48 h, the detectable levels of radioactivity were confined mainly to the excretory organs. This study showed that after occlusive cutaneous application of [14C]-test substance to the rat the radioactivity was rapidly absorbed, fairly evenly distributed in tissues and was rapidly excreted mainly via the urine (BASF SE. 1979).
A preliminary investigation of the metabolism of the [14C]-test substance has been performed by analysis of urine and faeces, collected after a single cutaneous application of 1 mg/kg bw to female Boots Wistar rats. At least four metabolites of the test substance, which were more polar than the parent compound, were observed in either samples of raw urine or ether extracts of urine. A similar pattern was observed in faeces with an additional radioactive component. Levels of free [14C]-test substance, 2 to 8 % in the urine and 8% in the faeces, were recorded. They must be regarded as an underestimate however because of the relatively high volatility of this compound. Enzyme hydrolysis with beta-glucuronidase and aryl sulphatase indicated that one of the polar metabolites of [14C]-test substance may be a sulphate conjugate (BASF SE. 1980).
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