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Diss Factsheets
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EC number: 211-463-5 | CAS number: 646-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION
- 1,3-Dioxolane is classified as non-irritating
EYE IRRITATION
- 1,3-Dioxolane causes serious eye damage and is classified as Category 1 (irreversible effects on the eye)
REPEATED DOSE INHALATION
- no irritating effects to the respiratory tract were observed
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In an eye irritation study (Auletta, 1980), 1,3-dioxolane showed irritating effects on the cornea, iris and conjunctivae. Irritating effects on cornea and conjunctivae were not fully reversible at termination of the study at 72 h. An in vitro study was performed according to the OECD TG 437. 1,3-Dioxolane was applied undiluted for 10 minutes and incubated for 120 minutes. The in vitro irritancy score determined in this study (115.7) indicates that 1,3-Dioxolane causes serious eye damage.
Based on the available data, the classification for 1,3-dioxolane is Eye Dam. 1, with the Hazard Statement H318: Causes serious eye damage (according to Regulation (EC) No 1272/2008).
In a skin irritation study, 1,3-dioxolane applied under occlusion (for 24 h) showed some irritation. Although the score at t = 48 h is missing, the mean overall irritation score is below the relevant score trigger for classification (score of 2.0 to be observed with 4 h application under semi-occlusion). An in vitro study was performed according to the OECD TG 439. 1,3-Dioxolane was applied undiluted for 15 minutes on reconstructed human epidermis tissue and incubated for 42 hours. The relative mean viability of the test item treated tissues was 78.8% after the 15-minute exposure period and 42-hour post-exposure incubation period. The test item was therefore classified as non-irritant
In repeated dose inhalation studies with 1,3-dioxolane no irritating effects were observed.
Justification for classification or non-classification
According to the studies submitted,1,3-dioxolane is not irritating to the skin and to the respiratory system, but causes serious eye damage (Category 1) with Hazard Statement H318: Causes serious eye damage (in compliance with Regulation (EC) No 1272/2008).
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