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EC number: 204-541-5 | CAS number: 122-40-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: oral
LD50 was considered to be 3730mg/kg body weight.When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.
Acute toxicity: dermal
The acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Acute oral toxicity study of benzylideneheptanal was performed in Rat
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Amyl cinnamic aldehyde
- Molecular formula:C14H18O
- Molecular weight :202.295 g/mole
- Substance type:organic
- Physical state:Liquid
- Purity:No data available
- Impurities (identity and concentrations):No data available - Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: 18 hr
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data availabl - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data available
- Doses:
- 3730mg/kg
- No. of animals per sex per dose:
- Total:10
male:5
female:5 - Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days (or other?):1weeks
- Frequency of observations and weighing: Observations for mortality and overt signs of effect were made daily.
- Necropsy of survivors performed: No data available
- Other examinations performed: clinical signs, body weight, other: No data available - Statistics:
- Litchfield & Wilcoxon (1949).
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 730 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 190 - 4 370
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed on 4hr-5days
- Clinical signs:
- other: Somnolence (general depressed activity),Prophryrin -like deposit around nose and eyes
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 3730mg/kg body weight.When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.
- Executive summary:
Acute oral toxicity study was done in both sex of Osborne Mendelrat using test material 2-benzylideneheptanal (122-40-7).10 animals were used. Fasting period before study was 18hr .water provided ad libitum .Test material given by oral gavage .Clinical signs observed after a few hours,Somnolence (general depressed activity),Prophryrin -like deposit around nose and eyes preceded death.50% mortality observed on 4hr-5days at dose concentration 3730.0mg/kg body weight.Hence LD50 was considered to be 3730mg/kg body weight.When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 730 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-reviewed journal.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer below
- Principles of method if other than guideline:
- The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
- Limit test:
- no
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Amyl cinnamic aldehyde (2-benzylideneheptanal)
- Molecular formula: C14H18O
- Molecular weight : 202.2952 g/mole
- Substance type: Organic
- Physical state:Liquid - Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Females (if applicable) nulliparous and non-pregnant: No data available
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available - Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 4 rabbits/sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: No data available
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available - Statistics:
- No data available
- Preliminary study:
- No data available
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: There was no evidence of toxicity at the dose tested.
- Mortality:
- No mortality observed upto 2000.0 mg/kg bw
- Clinical signs:
- other: There was no evidence of toxicity at the dose tested.
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: not classified based on CLP criteria
- Conclusions:
- The acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
- Executive summary:
The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route. Four rabbits were administered amyl cinnamic aldehyde (2-benzylideneheptanal) dermally at 2000 mg/kg bw. No evidence of toxicity was seen. No mortality was observed. hence the acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Data is Klimisch 2 and from peer-reviewed journal.
Additional information
Acute oral toxicity
In different studies ,2-benzylideneheptanal (CAS No. 122-40-7)has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats for ,2-benzylideneheptanal (CAS No. 122-40-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In experimental study given by P.M. Jenner, E.C. Hagan, Jean M. Taylor, E.L. Cook, O.G. Fitzhugh (Food and Cosmetics Toxicology Volume 2, 1964, Pages 327–343) Acute oral toxicity study was done in both sex of Osborne Mendelrat using test material 2-benzylideneheptanal (122-40-7).10 animals were used. Fasting period before study was 18hr .water provided ad libitum .Test material given by oral gavage .Clinical signs observed after a few hours, Somnolence (general depressed activity),Prophryrin -like deposit around nose and eyes preceded death.50% mortality observed on 4hr-5days at dose concentration 3730.0mg/kg body weight. Hence LD50 was considered to be 3730mg/kg body weight. When Osborne Mendel rats were treated with 2- benzylideneheptanal (122-40-7) orally.
Based on the prediction done by using the Danish (Q)SAR Database, the acute toxicity study was estimated to evaluate the toxic effects of administration of 2-benzylideneheptanal (CAS No. 122-40-7) in rat by the oral route. 50% mortality observed at 3300.0 mg/kg/day in treated rats. Therefore, the acute oral median lethal dose (LD50) of 2-benzylideneheptanal in rat was estimated to be 3300.0 mg/kg/day.
Also it is further supported by experimental study given byD.L.J. Opdyke(Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Page 915) on structurally similar read across substanceusing α-hexylcinnamaldehyde (CAS No. 101-86-0).The acute oral toxicity study of α-hexylcinnamaldehyde (CAS No. 101-86-0) was carried out using Wistar rats (10 males/dose).The dose concentration 1780, 2670, 4000 and 6000 mg/kg-bw were administered orally and were observed for 14 days. The observed clinical signs of toxicity were decreased activity, lethargy and anorexia. The 50% mortality was reported at 3100.0 mg/kg b.wt with 95% confidence limit of 2450.0 – 3750.0 mg/kg. Thus, LD50 was considered to be 3100.0 mg/kg b.wt with 95% confidence limit of 2450.0 – 3750.0 mg/kg. When rats were treated with of α-hexylcinnamaldehyde (101-86-4) orally.
Also it is further supported by experimental study given byD.L.J. Opdyke(Food and Cosmetics Toxicology Volume 16, Supplement 1, 1978, Page 659) on structurally similar read across substanceusing p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butyl benzyl)propionaldehyde)(80-54-6).The acute toxicity study was conducted to evaluate the toxic effects of administration of p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butyl benzyl)propionaldehyde) (No. 80-54-6) in rat by the oral route. Rats (10/sex/dose) were administered 1220, 2470, 5000, and 10140 mg/kg-bw (1.22, 2.47, 5.0 and 10.14 g/kg-bw) of p-t-butyl-alphamethylhydrocinnamaldehyde orally. The observed clinical signs of toxicity were diarrhea, piloerection, lethargy, flaccidity, ataxia and coma. 50% mortality was observed at dose 3700 mg/kg bw. Hence The LD50 was considered to be 3700.0 mg/kg b.wt with 95% confidence limit of 2600.0 – 5400.0 mg/kg. When rats were treated with p-t-Butyl-alpha-methylhydrocinnamaldehyde (2-(4-tert-butyl benzyl)propionaldehyde)(80-54-6) orally.
Thus, based on the above studies and predictions on ,2-benzylideneheptanal (CAS No. 122-40-7)and it’s read across substances, it can be concluded that LD50 value is 3730 mg/kg bw. Thus, comparing this value with the criteria of CLP2-benzylideneheptanal (CAS No. 122-40-7)can be “Not classified” for acute oral toxicity.
Acute dermal toxicity
In different studies,2-benzylideneheptanal (CAS No. 122-40-7)has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits for2-benzylideneheptanal (CAS No. 122-40-7).The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.
In experimental study given byD.L.J.Opdyke (Food and Cosmetics Toxicology Volume 11, Issue 5, October 1973, Pages 855-856)The acute toxicity study was examined to evaluate the toxic effects of administration of amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) in rabbit by the dermal route. Four rabbits were administered amyl cinnamic aldehyde (2-benzylideneheptanal) dermally at 2000 mg/kg bw. No evidence of toxicity was seen. No mortality was observed. hence the acute dermal median lethal dose (LD50) was considered to be greater than 2000 mg/kg bw (>2000 mg/kg bw). When rabbits were treated with amyl cinnamic aldehyde (2-benzylideneheptanal) (CAS No. 122-40-7) by dermal application.
The acute toxicity study was predicted using OECD QSAR toolbox version 3.4 (2017); to evaluate the toxic effects of administration of 2-benzylideneheptanal (CAS No. 122-40-7) in rabbit by the dermal route. 50% mortality observed at 5788.13 mg/kg bw in the treated rabbits. Therefore, the acute oral median lethal dose (LD50) was estimated to be 5788.13 mg/kg b.wt. When rabbits were treated with 2-benzylideneheptanal (122-40-7) via dermal route.
Also these results are further supported by the experimental study conducted in a non GLP laboratory (Sustainability Support Services (Europe) AB has the letter of access) for the structurally similar read across substance Cinnamaldehyde (104-55-2), The acute dermal toxicity study of Cinnamaldehyde (104-55-2) was performed on 20 male and female wistar rats according to OECD guideline-402. Approximate 10% back skin of total body surface area was prepared 24 hr prior to application of test material. Test material in dose concentration 2000mg/kg bw applied for 24hr in group I and group II animals. All the animals were acclimation for period of one week and provided with Fresh and clean water filtered through ‘Aqua Guard on line water filter’, was kept in glass bottles; Ad libitum. All animals were observed for clinical signs, body weight and mortality. The necropsy was performed on all animals at termination of the study. No incidence of mortality was observed in Wistar albino rats after application of test compound. The Wistar albino rats treated with the test compound showed moderate to severe clinical signs of intoxication viz; decrease in cage side activity, lacrimation and abdominal respiration. The local signs of dermal toxicity viz; erythema and edema were observed. This condition was observed upto 6 days from the day of application of test compound. The body weight of all the animals was recorded on day 0 (pre treatment) and then 7th and 14th (post treatment) showed slightly decrease on day 7th while normal increase on day 14th when compared to day 0. Necropsy finding did not reveal any significant gross pathological changes in any of the Wistar albino rat. Hence the acute dermal LD50 was considered to be more than 2000 mg/kg b.wt. (> 2000 mg/kg b.wt.) When Wistar albino rats were treated with Cinnamaldehyde (104-55-2) applied by dermal route
Also it is further supported by experimental study given by D.L.J. Opdyke(Food and Cosmetics Toxicology Volume 16, Supplement 1, 1978, Page 659)on structurally similar read across substancep-t-Butyl-alpha-methyl hydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde) (CAS No. 80-54-6),The acute dermal toxicity study of p-t-Butyl-alpha-methyl hydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde) (CAS No. 80-54-6) in rabbit was determined. Rabbits (10/sex/dose) were administered p-t-butyl-alpha-methyl hydrocinnamaldehyde via the dermal route of exposure. No animals died at any dose. The observed clinical signs of toxicity were erythema (mild to moderate) and edema (mild to moderate). Hence LD50 was considered to be > 5000.0 mg/kg b.wt. When rabbits were treated with p-t-butyl-alpha-methyl hydrocinnamaldehyde (2-(4-tert-butylbenzyl) propionaldehyde)(80-54-6) via dermal application.
Also it is further supported by experimental study given by D.L.J. Opdyke (Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Page 915)on structurally similar read across substanceα-hexylcinnamaldehyde (CAS No. 101 -86 -0),Acute dermal toxicity study of α-hexylcinnamaldehyde (CAS No. 101 -86 -0) in rabbit was determined. Rabbits (two females) were administered alpha-hexylcinnamaldehyde dermally on a clipped area of skin at doses of 1000, 2000 or 3000 mg/kg bw for 24 hours and observed for 7 days. No animals died at any dose. Moderate erythema and occasional sloughing was observed, which was attributed to poor animal handling techniques. Hence LD50 was considered to be >3000.0 mg/kg b.wt. When rabbits were treated with alpha-hexylcinnamaldehyde (101-86-0) via dermal application.
Thus, based on the above studies and predictions on2-benzylideneheptanal (CAS No. 122-40-7)and its read across substances, it can be concluded that LD50 > 2000 value is mg/kg bw. Thus, comparing this value with the criteria of CLP2-benzylideneheptanal (CAS No. 122-40-7)can be “Not classified” for acute dermal toxicity.
Justification for classification or non-classification
Thus, comparing this value with the criteria of CLP 2-benzylideneheptanal (CAS No. 122-40-7)can be “Not classified” for acute oral and dermal toxicity.
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