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EC number: 204-541-5 | CAS number: 122-40-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from J-check authoritative database
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- Acute toxic effect on the Daphnia species was observed by using the chemical alpha-Amyl cinnamaldehyde.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): alpha-Amyl cinnamaldehyde
- Molecular formula (if other than submission substance): C14H18O
- Molecular weight (if other than submission substance): 202.2952mg/l
- Smiles notation (if other than submission substance): c1(\C=C(\CCCCC)C=O)ccccc1
- InChl (if other than submission substance): 1S/C14H18O/c1-2-3-5-10-14(12-15)11-13-8-6-4-7-9-13/h4,6-9,11-12H,2-3,5,10H2,1H3/b14-11-
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type: organic
- Physical state: No data
- Analytical purity: No data - Analytical monitoring:
- not specified
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- Daphnia sp.
- Details on test organisms:
- No data
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- No data
- Post exposure observation period:
- No data
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.28 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No data
- Results with reference substance (positive control):
- No data
- Reported statistics and error estimates:
- No data
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the immobilization of the test organism daphnia species by the alpha-Amyl cinnamaldehyde, the EC50 is 0.28mg/l.
- Executive summary:
Acute toxic effect on the Daphnia species was observed by using the chemical alpha-Amyl cinnamaldehyde, with the 48hrs total exposure period.
Based on the 0.28mg/l EC50 value, it can be concluded that the test chemicalalpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the classification criteria.
Reference
Description of key information
Based on the experimental key study (J-check authoritative databases, 2016) acute toxic effect on the Daphnia species was observed by using the chemical alpha-Amyl cinnamaldehyde(122 -40 -7) 2 -benzylideneheptanal, with the 48hrs total exposure period. Based on the 0.28mg/l EC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.28 mg/L
Additional information
Based on the various experimental data and prediction data for the target chemical have been reviewed to determine the toxic nature of alpha-Amyl cinnamaldehyde (122-40-7), IUPAC name 2 -benzylideneheptanal on the growth of acquatic invertebrates.The studies are as mentioned below:
Based on the experimental key study (J-check authoritative databases, 2016) acute toxic effect on the Daphnia species was observed by using the chemical alpha-Amyl cinnamaldehyde, with the 48hrs total exposure period. Based on the 0.28mg/l EC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic acute category 1 as per the classification criteria.
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 0.946mg/l for CAS name 122 -40 -7 in 48 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic acute 1 category as per the criteria mentioned in CLP regulation.
Similarly in the supporting study (HPVIS, 2017) acute toxic effect on the Daphnia species was carried out by using the chemical alpha-Amyl cinnamaldehyde for 48 hrs. Static method was use for the study with different concentrations. At various concentration EC value and NOEC obtain at 48 hours is EC0=0.4 mg/L and 48 hr. EC50=1.1 mg/L; EC100=2.8 mg/l and NOEC is 0.4 mg/l. The number of Daphnis exhibiting immobilization at 48hours for duplicate runs at each mean measured concentration was also observed. In control and 0.1mg/l no changes were obtain. But in 0.7 mg/l =4/40 & 5/40; 1.4 mg/L= 25/40 & 31/40; and 2.8 mg/L= 40/40 & 32/40. Based on the 1.1mg/l EC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in aquatic chronic category 2 as per the classification criteria.
In second supporting study (Inventory Multitiered Assessment and Prioritisation, NICNAS, 2017) acute toxic effect on the Daphnia magna was observed by using the chemical alpha-Amyl cinnamaldehyde. Based on the 1.1mg/l EC50 value, it can be concluded that the test chemical alpha-Amyl cinnamaldehyde can be considered as toxic to the aquatic organism daphnia at environment revelent concentration and thus can be considered to be classified in chronic category 2 as per the classification criteria.
Although 2 study from secondary sources gives the EC50 value greater than 1, but the data from the J-check authoritative databases (K2) which was the key study, EC50 was 0.28mg/l and performed as per the OECD guideline. Thus we consider that the chemical alpha-Amyl cinnamaldehyde to be toxic to aquatic environment and can be considered to be classified in acute category 1as per the CLP classification criteria.
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