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Diss Factsheets
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EC number: 201-964-7 | CAS number: 90-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was not a standardised method but it was well described
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity of substituted phenols to Rana japonica tadpoles and mechanism-based quantitative structure-activity relationship (QSAR) study
- Author:
- Wang X., Dong Y., Wang L. and Han S.
- Year:
- 2 001
- Bibliographic source:
- Chemosphere, 44 : 447-455
- Reference Type:
- publication
- Title:
- Quantitative structure-activity relationships for the toxicity to the tadpole Rana japonica of selected phenols
- Author:
- Wang X., Dong Y., Xu S., Wang L., and Han S.
- Year:
- 2 000
- Bibliographic source:
- Bull. Environ. Contam. Toxicol., 64 : 859-865
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- evaluate the toxicity on Tadpoles at 12h and 24h.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Guaiacol
- EC Number:
- 201-964-7
- EC Name:
- Guaiacol
- Cas Number:
- 90-05-1
- Molecular formula:
- C7H8O2
- IUPAC Name:
- Phenol
- Details on test material:
- It was provided by Department of Chemistry at Nanjing University and was of sufficient purity (analytical purity). Further purification was not necessary.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION:
- Method: All exposures took place at water temperature 22-25°C in a controlled environmental chamber (pH = 6.31). Aerated chloride-free water was used for preparing the stock solutions of chemical and test dilution.
A six-step concentration series in geometric grade ranging from no effect to 100% lethal concentration were set after range finding experiments.
Test organisms
- Test organisms (species):
- Rana sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: tadpoles
- Strain: Rana Japonica
- Source: collected from a permanent pond in Nanjing.
- Age at study initiation: 30 day-old
- Weight at study initiation: 0.09 +/- 0.01 g
- Length at study initiation: 2.5 +/- 0.1 cm
- Method of breeding: eggs and the resulting tapdoles were cultured in aerated stream water (Cl-: 3.40 mg/L, pH: 7.74, dissolved oxygen concentration: 9.6 mg/L, Na+: 2.35 mg/L; Ca2+: 48 mg/L) in the laboratory at romm temperature (22-25°C).
- Feeding during test
- Food type: an excess of rinsed, salt free canned spinach
- Amount: no data
- Frequency: daily
ACCLIMATION: none
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 12 h
- Remarks on exposure duration:
- 12 and 24 hours
Test conditions
- Test temperature:
- 22-25°C
- pH:
- measured
- Nominal and measured concentrations:
- a six-step concentration series in geometric grade ranging from no effect to 100% lethal concentration were set after range finding experiments.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: 1000 ml pyrex beaker containing 500 ml test solution or aerated chloride-free water.
- Aeration: no
- Renewal rate of test solution: every 6 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
TEST MEDIUM / WATER PARAMETERS: aerated chloride-free water
OTHER TEST CONDITIONS:
- Photoperiod: 14 (day) /10 (night) hours.
EFFECT PARAMETERS MEASURED: mortality
TEST CONCENTRATIONS
- Spacing factor for test concentrations: six-step concentration series in geometric grade ranging from no effect to 100% lethal concentration were set after range finding experiments.
- Range finding study: no data - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 12 h
- Dose descriptor:
- LC50
- Effect conc.:
- 430.44 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 392.57 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Reported statistics and error estimates:
- Logarithms of inverse of median lethal concentrations after 12-h and 24-h exposure were calculated using non-linear regression in STATISTICA software.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.