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EC number: 401-950-2 | CAS number: 31506-43-1 3-(DIMETHYLAMINO)PROPYL UREA; HST 2844
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- In accordance with Japanese Industrial Standards (JIS) K 0102- 1998section 14.1
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(dimethylamino)propylurea
- EC Number:
- 401-950-2
- EC Name:
- 3-(dimethylamino)propylurea
- Cas Number:
- 31506-43-1
- Molecular formula:
- C6H15N3O
- IUPAC Name:
- [3-(dimethylamino)propyl]urea
- Test material form:
- liquid: viscous
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- Activated sludge sampling sites and date
Sampling sites:
On-site sludge sampling was carried out at the following 10 locations in Japan.
- Fushikogawa city sewage plant (Sapporo-shi, Hokkaido)
- Fukashiba industrial sewage plant (Kashima-gun, Ibaraki)
- Nakahama city sewage plant (Osaka-shi, Osaka)
- Ochiai city sewage plant (Shinjuku-ku, Tokyo)
- Kitakarni River (Ishinomaki-shi, Miyagi)
- Shinano River (Niigata-shi, Niigata)
- Yoshino River (Tokushima-shi, Tokushima)
- Lake Biwa (Otsu-shi, Shiga)
- Hiroshima Bay (Hiroshima-shi, Hiroshima)
- Dookai Bay (Kitakyushu-shi, Fukuoka)
Date March, 2002
Sludge sampling
City sewage
Return sludges from sewage plants were collected.
Rivers, lake and sea
Surface water and surface soil which was in contact with the atmosphere were collected.
Preparation of activated sludge
Activated sludge was prepared as follows to maintain its uniformity.
The filtrate (5 L) of the supernatant of the activated sludge cultivated about for 3 months was mixed with the mixed filtrate (5 L) of the supernatant of a sludge collected newly at each location. The mixed filtrate (10 L) was aerated after the pH value of the mixture was adjusted to 7.0 +/- 1.0.
The activated sludge cultivated the mixed filtrate (10 L) of the supernatant of sludge collected at the ten locations subject to cultivation as per below. Prefiltered open air was used.
Cultivation
Roughly 30 minutes after ceasing aeration of the sludge mixture, supernatant corresponding to about 1/3 of the whole volume was removed. Dechlorinated water was added to the remaining portion so that the total volume reached 10 L. This mixture was aerated, and then a predetermined amount of synthetic sewage was added to the mixture so that the concentration of the synthetic sewage was 0.1 wt% in the volume of dechlorinated water added. This procedure was repeated once every day. Cultivation was carried out at 25 +/- 2 °C.
Synthetic sewage
Glucose, peptone and potassium dihydrogenphosphate were dissolved in dechlorinated water to obtain 50 g/L of the solution for each component. The pH of the solution was adjusted to 7.0 +/- 1.0 with sodium hydroxide.
Control and use
During cultivation, the appearance of the supernatant, sedimentation of the sludge, formation of flock, pH, dissolved oxygen concentration in the solution and temperature were checked to maintain a normal state of sludge. It was confiied that these were within the scope of the control standard stipulated in the "Testing Methods for New Chemical Substances", and these results were stored as raw data. Microflora in the activated sludge was microscopically observed and sludge with no abnormal symptoms was used for the test.
Inspection of activity and date of initiation of use of activated sludge
Inspection of activity
Activity of the sludge was assessed using a reference item.
Date of initiation of use April 16, 2002 - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1
- Sampling time:
- 28 d
- Parameter:
- % degradation (TOC removal)
- Value:
- 2
- Sampling time:
- 28 d
- Key result
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 1
- Sampling time:
- 28 d
- Details on results:
- Results:
1) Percentagebiodegradation by BOD: 0 %, 3 %, 1 %, average 1 %
2) Percentage biodegradationby TOC: 2 %, 2 %, 3 %, average 2 %
3) Percentage biodegradation by HPLC 1 %, 1 %, 0 % average 1 %
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- A mixture of the reaction products (1-(3-(Dimethylamino)propyl)urea (CAS 31506-43-1, EC 401-950-2, monoDMAPAU) )and 1,3-bis[3-(dimethylamino)propyl]urea (CAS 52338-87-1, EC 257-861-2, bisDMAPAU) was tested in an OECD 301c modified MITI test for biodegradation. Under the present test conditions, the test item was not biodegraded.
- Executive summary:
Under the present conditions, about theoretical amount of two components of the test item remained and average percentage biodegradation by BOD and TOC were 1 % and 2 %, respectively. The results indicate that the test item was neither biodegraded nor changed.
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