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EC number: 414-780-9 | CAS number: 38585-74-9 A-87440.0; A-87440.00
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 01 - February 03, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- and OECD nr. 202 part 1
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-thiazolylmethanol
- EC Number:
- 414-780-9
- EC Name:
- 5-thiazolylmethanol
- Cas Number:
- 38585-74-9
- Molecular formula:
- C4H5NOS
- IUPAC Name:
- (1,3-thiazol-5-yl)methanol
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- samples (50 ml in duplicate) taken from control and each exposure groups (replicates pooled) at 0 hours and 48 hours and analyzed.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- 2.2, 4.6, 10, 22, 46, 100, 220mg/l (nominal) solutions of A-87440.0 in Elendt M7 medium
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Source: IRChA, France
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- Evaluations at 24hr and 48hr
Test conditions
- Test temperature:
- 20°C ± 1°C
- pH:
- 7.3 - 7.5
- Dissolved oxygen:
- 8.6 - 8.7mg/L
- Nominal and measured concentrations:
- Nominal: 2.2, 4.6, 10, 22, 46, 100, 220mg/L
Measured: 2.1, 4.2, 9.1, 20, 43, 93, 210mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass jars
- Type: loosely covered with aluminium foil to help reduce evaporation.
- fill volume: 200 ml
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
OTHER TEST CONDITIONS
- Photoperiod: 16hr light, 8hr dark
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 110 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 86 - 130 (95% CL)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 44 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 33 - 58 (95% CL)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- HIghest conc resulting in 0% immobilisation: 9.1mg/l
Lowest conc resulting in 100% immobilisation: 210mg/l
Any other information on results incl. tables
All results expressed in terms of measured concentrations. Measured concentrations ranged from 90 -95% of nominal at 0 hours and 89 -102% of nominal at 48 hours.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48hr EC 50 (immobilisation) value for A-87440.0 with Daphnia Magna is 44mg/l
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