Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-115-1 | CAS number: 94720-90-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 July 2012 - 22 october 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of (1R)-1,2,2-trichloro-2-fluoroethyl trifluoromethyl ether and (1S)-1,2,2-trichloro-2-fluoroethyl trifluoromethyl ether
- EC Number:
- 938-115-1
- Cas Number:
- 94720-90-8
- Molecular formula:
- C3HCl3F4O
- IUPAC Name:
- Reaction mass of (1R)-1,2,2-trichloro-2-fluoroethyl trifluoromethyl ether and (1S)-1,2,2-trichloro-2-fluoroethyl trifluoromethyl ether
- Test material form:
- liquid
- Details on test material:
- - Description: colourless liquid
- Batch 02072012
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Italia S.p.A., Calco (Lecco), Italy
- Date of arrival at the Testing Facilities: 26 July 2012
- Age at the date of arrival: 6 to 8 weeks old
- Weight at the date of arrival: 176 to 200 grams
- Housing: Polysulphone solid bottomed cages measuring 59x38.5x20 cm (during acclimatisation) and 42.5x26.6x18 cm (during the study) with nesting material
- Number of animals/cage: up to 5/cage (during acclimatisation) and individually caged (during study)
- Diet: ad libitum
- Water: Drinking water ad libitum
- Acclimation period: At least 5 days
ALLOCATION TO TREATMENT GROUP:
- Allocation: Random at arrival
- Animal identification: Permanent, following arrival, by a combination of ear notch (units) and tattoo on the hind feet. Males and females were identified by even and odd numbers, respectively.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 2°C
- Humidity (%): 55% ± 15%
- Air changes (per hr): Approximately 15 to 20 air changes per hour
- Photoperiod (hrs dark / hrs light): Artificial (fluorescent tubes), daily light/dark cycle of 12/12 hours
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - A single area was clipped free of hair on the dorsal surfaces of the trunk of each animal (approximately 10% of body surface).
- An aliquot of the supplied test item was spread evenly over an area of approximately 10% of the body surface area. A patch of surgical gauze covered by a strip of synthetic film was placed over the treated site and the whole assembly held in place by encircling the trunk of the animal with a length of elastic adhesive bandage, this forming a semi-occlusive barrier.
- After exposure, the adhesive bandage and gauze patch were removed. The treatment area was cleaned by gentle swabbing of the skin with cotton wool soaked with lukewarm water. - Duration of exposure:
- Treatment: once only,for 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 animals/sex/group
- Control animals:
- not required
- Details on study design:
- IN LIFE OBSERVATIONS:
- Mortality and morbidity: Twice daily.
- Clinical signs: day of dosing (on dosing, approximately 1, 2 and 4 hours after dosing), and daily thereafter (for 14 days)
- Body weight: allocation (Day –1), Days 1, 8 and 15
- Termination: day 15.
- Euthanasia method: Carbon dioxide narcosis.
- Necropsy procedure: Necropsy was carried out on all animals (gross necropsy examination for both external and internal abnormalities, with particular attention to the treatment site).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- other: No clinical signs were observed in male or female animals after treatment during the observation period.
- Gross pathology:
- No abnormalities were found at necropsy examination performed on all animals at termination of the study.
No abnormalities were observed on the treated site of any animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item, TRICHLOROETHYLIC ADDUCT was assessed in an acute dermal toxicity in rats according to the OECD guideline 402.
The test item has no toxic effect in the rat following dermal exposure over a 24 hour period at a level of 2000 mg/kg.
The lack of mortality demonstrates the LD50 to be greater than 2000 mg/kg. - Executive summary:
The acute toxicity of TRICHLOROETHYLIC ADDUCT was investigated following dermal administration of a single dose to the rat, and according to the OECD guideline 402.
A single dose of 2000 mg/kg was administered to a group of 5 male and 5 female animals for 24 hours. After 14 days, all animals were killed and subjected to necropsy examination.
No mortality occurred and no clinical signs were observed in male or female animals during the observation period.
The body weight changes observed during the study were within the expected range for this species and age of animals.
No abnormalities were found at necropsy in the animals at termination of the study.
No abnormalities were observed at the treated site.
These results indicate that the test item, TRICHLOROETHYLIC ADDUCT, has no toxic effect in the rat following dermal exposure over a 24 hour period at a level of 2000 mg/kg. The lack of mortality demonstrates the LD50 to be greater than 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.