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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 206-337-1 | CAS number: 328-84-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
From the ECHA disseminated dossier acute toxicity is gathered (d.d. 2014-08-20). The LD50 for acute oral toxicity in rats was 1.96 mL/kg bw (2800 – 3340 mg/kg bw). The lethal concentration after 4 hours of inhalation exposure was determined to be more than 15,860 mg/m3 air for rats. The LD50 for Wistar rats exposed after dermal application (OECD 402, GLP) was determined to be more than 2000 mg/kg bw. For rabbits the LD50 was determined to be more than 5000 mg/kg bw after dermal application.
Additional information is available in a report (BG Chemie Toxikologische bewertungen, Nr. 89, 1997), in which a summation of study results is presented, for a structural analogue of 3,4-dichloro-α,α,α-trifluorotoluene. It is stated that 3-chloro-α,α,α-trifluorotoluene has a very low toxicity in rats after acute oral exposure. The LD50 was more than 5000 mg/kg bw. The LC50 after 4 hours of inhalation exposure is more than 23,600 mg/m3 air. Clinical signs observed (impairment of motor skills, effects on breathing, drowsiness, and lacrimation) were caused by effects on the central nervous system. The effects observed were reversible within 3 to 6 days after application. Body weight was not affected.
Justification for classification or non-classification
Based on the high LD50 values for both 3,4-dichloro-α,α,α-trifluorotoluene and its structural analogue 3-chloro-α,α,α-trifluorotoluene, classification for oral, inhalation and dermal acute toxicity is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substance and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.