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EC number: 434-800-1 | CAS number: 121776-33-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Deviations:
- yes
- Remarks:
- The relative humidity was not maintained between 40% and 60%, however no explanation for this marked deviation was provided.
- GLP compliance:
- yes
- Test type:
- other: Limit test
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 434-800-1
- EC Name:
- -
- Cas Number:
- 121776-33-8
- Molecular formula:
- C11H13CL2NO3
- IUPAC Name:
- 2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one
- Reference substance name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- IUPAC Name:
- 3-(Dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine
- Test material form:
- other: Brown particles
- Details on test material:
- - Name of test material (as cited in study report): MON 13900
- Substance type: Brown particles
- Analytical purity: 96.4%
- Lot/batch No.: DAY-8912-1370T
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sprague Dawley Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratory, Portage, MI
- Age at study initiation: Six weeks
- Weight at study initiation: Males (204±5 g), females (153±2 g)
- Housing: Individual
- Diet (e.g. ad libitum): Feed (Purina Mills Rodent Chow #5002)
- Water: Ad libitum)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.2 ± 0.8 ⁰C
- Humidity (%): 20.9 ± 0.7%
- Air changes (per hr): 87.6 ± 3 L/min
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The exposure chamber was a 2,500 L New York University-style stainless steel chamber with a pyramidal top and bottom. During exposure, animals were placed in individual stainless steel wire mesh cages, positioned in one tier in the chamber. The test substance was introduced using a jet mill which milled and fed the test material into an aerosol neutralizer. The aerosol passed through the neutralizer prior to entering the exposure chamber. The chamber concentration of test substance was controlled by regulating the speed at which the twin screw feed mechanism fed test substance into
the jet mill. Chamber airflow, temperature, and percent relative humidity was monitored and recorded approximately every 30 min. Mean airflow was determined to be 87.6±3.0 L/min. Mean temperature and relative humidity were 20.2±0.8⁰C and 20.9±0.7%, respectively. Oxygen level (21%) was determined once during the exposure using an electronic sensor. The equilibration period (T99) was determined to be 13.1 min. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 2.3 mg/L
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- no
- Details on study design:
- Animals were observed hourly during exposure; however, the placement of cages allowed only limited observation of the animals. Mortality and moribundity were checked twice daily. Animals were observed for signs of toxicity immediately following exposure and once daily during the 14-d observation period after cessation of exposure. Body weights were determined on the exposure day (prior to exposure) and 2, 7, and 14 d following exposure. All animals were sacrificed 14 d after exposure and subjected to gross pathological examinations.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 2.3 mg/L was the highest attainable concentration.
- Mortality:
- No
- Clinical signs:
- other: Immediately after exposure (Day 0), clear nasal discharge was noted in one male and perioral wetness was noted in two males and four females. On post-exposure Day 1, red/brown perinasal encrustation was noted in two males and three females. All animals ap
- Body weight:
- All animals lost weight from Day 0 to Day 2. By post-exposure Day 14, all animals exceeded their pre-exposure weights.
- Gross pathology:
- No gross abnormalities were observed at final necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the test conditions, the acute inhalation LC50 of MON 13900 was >2.3 mg/L in rats.
- Executive summary:
A study was conducted to assess the acute inhalation toxicity of MON 13900 according to the EPA OPP 81-3 Guideline in compliance with GLP.
Five male and five female rats were exposed (whole body) for a single continuous 4 h period to an atmosphere of aerosolized test substance dust at the highest attainable mean analytical exposure concentration of 2.3 mg/L in air.
No deaths occurred, therefore, the LC50 was greater than 2.3 mg/L.
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