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EC number: 200-826-3 | CAS number: 74-97-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 948
Materials and methods
- Principles of method if other than guideline:
- Single inhalation and 5-day repeated dose toxicity study.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Bromochloromethane
- EC Number:
- 200-826-3
- EC Name:
- Bromochloromethane
- Cas Number:
- 74-97-5
- Molecular formula:
- CH2BrCl
- IUPAC Name:
- bromo(chloro)methane
- Details on test material:
- - Name of test material (as cited in study report): monochloromonobromomethane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 20 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
The animals were exposed to the test substance in an inhalation chamber according to the procedure described by Werner, H.C., Mitchell, J.L., Miller, J.W., and von Oettingen, W.F. (1943). - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Remarks on duration:
- (on one to five successive days)
- Concentrations:
- 7 to 17 mg/l.
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 72 hours.
- Necropsy of survivors performed: yes. Several mice of each series were killed for histologic study immediately and at intervals following completion of each of the one to five exposures. 79 mice were examined in total.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 12 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: (equiv. to 12171.05 mg/m3)
- Clinical signs:
- other: Nearly half the mice that died during or soon after a single inhalation exposure showed a whitish opacity of one or both eyes. This opacity appeared shortly before death and usually involved the entire cornea. It was not observed in mice that appeared to
- Gross pathology:
- The chief pathologic changes observed were marked visceral congestion, fatty degeneration of the liver, the kidney and occasionally of the heart, lipoid depletion of the inner portion of the adrenal cortex, interstitial pneumonitis and opacity of one or both eyes. Less frequent lesions were tubular necrosis and hemoglobin casts in the kidney. Fatty degeneration of the liver was the commonest and earliest lesion (observed after only a few hours' exposure and at 7 mg/l concentration). Fatty degeneration of the kidney was not seen in mice after a single seven hour exposure to 7 mg/l but was moderately severe in nearly all mice dying after a seven hour exposure to 12 mg/l concentration. Pneumonitis was not extensive and occurred in mice exposed daily between 24 and 72 hours after the end of the first exposure. One of 2 mice that died twenty-eight hours after the onset of a seven hour exposure to 17 mg/l showed hemoglobin casts in many scattered convulted tubules, and a few such tubules showed necrosis of some or all of their lining epithelial cells. Slight similar changes were seen in a few other exposed mice. In the heart, slight fatty degeneration occurred focally only in occasional exposed animals. Histologic examination of the opaque eyes observed in some animals showed foci of disorganization and edema in the substantia propria of the cornea with absence of the anterior epithelium or the posterior endothelium in some areas. The anterior chamber often contained some eosinophilic serous material or occasionally some polymorphonuclear and mononuclear cells.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The inhalative LC50 in mice is 12 mg/l (12171.05 mg/m3).
- Executive summary:
A single inhalation and 5 day repeated dose toxicity study was performed with the test substance bromochloromethane. Swiss mice were exposed to bromochloromethane for seven hours on one to five successive days to concentrations ranging from 7 to 17 mg/l. Several mice were killed for histologic study immediately and at intervals following completion of each of the one to five exposures. Marked visceral congestion, fatty degeneration of the liver, the kidney and occasionally of the heart, lipoid depletion of the inner portion of the adrenal cortex, interstitial pneumonitis and opacity of one or both eyes were observed. Less frequent lesions were tubular necrosis and hemoglobin casts in the kidney. It was found that the LC50 concentration was 12 mg/l (equivalent to 12171.05 mg/m3).
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