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Diss Factsheets
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EC number: 221-221-0 | CAS number: 3033-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Based on the European GEMS database 50-percentile value for the pH of the European surface water is about 7.8. Therefore the half-live of 177 days at pH 7.8 will be used further in the regional and continental risk assessment.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 177 d
- at the temperature of:
- 12 °C
Additional information
The conversion of EPTAC, as cited by studies in the EU Risk assessment report, seems to be considerably slower than in the key study (10.5 days in pH 7). This could be partly explained by higher testing temperature in the key study, from where the results have been calculated. As other studies (EPTAC hydrolysis and CHPTAC conversion) are conducted in environmentally relevant conditions, results from these studies seem to be more reliable. CHPTAC (3 -Chloro-2 -hydroxypropyltrimethylammonium chloride, CAS# 3327 -22 -8) is used for the production of cationic starch. Thus, CHPTAC is always transformed to EPTAC before the cationisation. In addition, the hydrolysis half-lives for EPTAC calculated from these studies are close to each other i.e. 177 days and 138 days at pH 7.8. Furthermore these hydrolysis half-lives are clearly longer compared to CHPTAC conversion rate (21 days at pH 7.8) whereas in the first EPTAC hydrolysis test half-life is shorter compared to CHPTAC. Longer EPTAC hydrolysis half-lives compared to CHPTAC can be observed from two other tests, namely adsorption test to sludge and the chronic Daphnia test. In the sludge test abiotic removal of EPTAC was slower (4-6 % in 3 days in abiotic and sterile controls) compared to CHPTAC (22-27 % in 3 days). In the 21 day Daphnia sp. test with EPTAC no significant removal of EPTAC was observed after 2 days, but in the similar test with CHPTAC approximately 30 % of the total sum was converted to EPTAC after 2 days. Therefore results from the latter EPTAC hydrolysis study will be used in the assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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