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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

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REACH

Fuels, diesel

EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).

Life Cycle description
Uses advised against

Toxicological information

Genetic toxicity: in vivo

Administrative data

Endpoint:: genetic toxicity in vivo
Remarks:: Type of genotoxicity: other: QSAR method
Type of information:: (Q)SAR
Adequacy of study:: weight of evidence
Reliability:: 2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:: other: Regulatory accepted model for assessment of chemical substances
Justification for type of information:: QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:: other company data
Title:: Unnamed
Year:: 2010

Materials and methods

Test guideline

Qualifier:: according to guideline
Guideline:: other: QSAR method

Principles of method if other than guideline:: QSAR Method:
Toxtree (Estimation of Toxic Hazard –A Decision Tree Approach) based on SMILES

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity);
The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents
GLP compliance:: no
Remarks:: not applicable to QSAR models
Type of assay:: other: QSAR method

Test material

Test material information

Details on test material:: data for components

Results and discussion

Any other information on results incl. tables

Overview of QSAR/SAR estimations on mutagenicity potential of Diesel Fuel

Method

Results

Remarks

Reference

Hexane, C₆H₁₄(CAS No. 110-54-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Heptane, C₇H₁₆(CAS No. 142-82-5)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Octane, C₈H₁₈(CAS No. 111-65-9)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Nonane, C₉H₂₀(CAS No. 111-84-2)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Decane, C₁₀H₂₂(CAS No. 124-18-5)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Hendecane, C₁₁H₂₄(CAS No. 1120-21-4)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Dodecane, C₁₂H₂₆(CAS No. 112-40-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Tridecane, C₁₃H₂₈(CAS No. 629-50-5)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Tetradecane, C₁₄H₃₀(CAS No. 629-59-4)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Pentadecane, C₁₅H₃₂(CAS No. 629-62-9)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Hexadecane, C₁₆H₃₄(CAS No. 544-76-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Heptadecane, C₁₇H₃₆(CAS No. 629-78-7)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Octadecane, C₁₈H₃₈(CAS No. 593-45-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Nonadecane, C₁₉H₄₀(CAS No. 629-92-5)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Eicosane, C₂₀H₄₂(CAS No. 112-95-8)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Toluene, C₇H₈(CAS No. 108-88-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Ethylbenzene, C₈H₁₀(CAS No. 100-41-4)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

p-Xylene, C₈H₁₀(CAS No. 106-42-3)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

o-Xylene, C₈H₁₀(CAS No. 95-47-6)

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

Negative for genotoxic carcinogenicity.

Negative for nongenotoxic carcinogenicity.

The decision logic is based on Benigni/Bossa rulebase (for mutagenicity and carcinogenicity)

Toxtree, v. 2.5.0

QSAR Method:

Toxtree (Estimation of

Toxic Hazard –A Decision Tree Approach) based on SMILES

Result:

No alerts for micronucleus assay (Class II)

The decision logic is based on Structure Alerts fort he in vivo micronucleus assay in rodents

Toxtree, v. 2.5.0

Applicant's summary and conclusion

Conclusions:: Data for components:
Negative for genotoxic carcinogenicity.
Negative for nongenotoxic carcinogenicity.
No alerts for micronucleus assay.

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Registration Dossier

Registration Dossier

Data platform availability banner - registered substances factsheets

Diss Factsheets

Fuels, diesel

Genetic toxicity: in vivo

Administrative data

Data source

Reference

Materials and methods

Test guideline

Test material

Test material information

Constituent 1

Results and discussion

Any other information on results incl. tables

Applicant's summary and conclusion