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Diss Factsheets
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EC number: 212-091-6 | CAS number: 762-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: poorly documented methods, no single values given
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding Toxicity data: List VII
- Author:
- Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, 30:5, 470-476
Materials and methods
- Principles of method if other than guideline:
- Concentrated vapor inhalation consists of subjecting groups of six male or female albino rats to a flowing stream of vapor-ladened air. The vapor-air mixture is generated by passing 2.5 liters/minute of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch inapproximately 50 ml of the test chemical contained in a gas-washing bottle.
- GLP compliance:
- no
- Test type:
- other: Estimation of exposure time where no mortality occurs in vapour-containing air flow.
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl phosphonate
- EC Number:
- 212-091-6
- EC Name:
- Diethyl phosphonate
- Cas Number:
- 762-04-9
- Molecular formula:
- C4H11O3P
- IUPAC Name:
- diethyl phosphonate
- Test material form:
- other: concentrated vapour
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 6 (total) male or female
- Control animals:
- no
- Details on study design:
- Inhalations are continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation
period killing about half the number of rats within 14 days is defined. - Statistics:
- not given
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: see remarks
- Effect level:
- other: no mortality
- Based on:
- other: concentrated vapour
- Exp. duration:
- 8 h
- Remarks on result:
- other: only the exposure time in the prepared air/concentrated vapor atmosphere with no mortality is given.
- Mortality:
- no mortality
- Clinical signs:
- other: not examined
- Body weight:
- not examined
- Gross pathology:
- not examined
Applicant's summary and conclusion
- Executive summary:
Inhalative exposure to a concentrated vapour atmosphere was tolerated by 6 male Wistar rats for 4 hours without mortality
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