Registration Dossier
Registration Dossier
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EC number: 203-561-1 | CAS number: 108-21-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study with basic documentation which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding Toxicity Data, List V.
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S. and Pozzani, U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Archives of Industrial Hygiene and Occupational Medicine, 10:61-68.
Materials and methods
- Principles of method if other than guideline:
- Evaluation of skin reactions in rabbits following 24-hr exposure.
- GLP compliance:
- no
- Remarks:
- pre-dates GLP
Test material
- Reference substance name:
- Isopropyl acetate
- EC Number:
- 203-561-1
- EC Name:
- Isopropyl acetate
- Cas Number:
- 108-21-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- isopropyl acetate
- Details on test material:
- Name of test material (as cited in study report): Acetic acid, isopropyl ester
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
Amount(s) applied (volume or weight with unit): 0.01 ml of undiluted sample. - Duration of treatment / exposure:
- 24 hours
- Observation period:
- No data
- Number of animals:
- 5
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: No data
- Time point:
- other: 24h
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- no data
- Irritant / corrosive response data:
- Isopropyl acetate received a Grade 1 in this assay (following administration of 0.01 ml ) indicating least visible capillary injection with the undiluted material.
Applicant's summary and conclusion
- Interpretation of results:
- other: no to slight irritation
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Interpretation must be made in the context of no occlusion during the exposure
- Executive summary:
Smyth et al (1954) reported Grade 1 irritation, the least visible capillary injection, following application of undiluted isopropyl acetate to the clipped skin of rabbits for 24 hours. This is interpreted as to indicate "no to slight irritation" potential. However, the study was performed without occlusion.
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