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Diss Factsheets
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EC number: 700-934-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Formaldehyde release of EUF in aqueous solution was investigated for a 1%(v/v) solution at 20°C and pH-values of 7.2, 9.2, and 4.0 in H2O/DMSO-D6 (90/10) using 13C-NMR spectroscopy. The investigation follows the OECD Guideline 111, which was modified slightly due to technical reasons. The reaction rate of hydrolysis was determined via measurement of the formaldehyde being released. It was found that at pH 7.2 and 9.2 the formaldehyde concentration reached a plateau after < 1 hours, while at pH 4 the reaction was slightly slower, reaching the plateau after 3-4 hours.The following formaldehyde release percentages, referring to the weighed sample, were determined: at pH 7.2 after 390 h approx. 25%, at pH 9.2 after 387 h approx. 26%, and at pH 4.0 after 295 h approx. 32% (maximal releasable formaldehyde is specified to be 46.1%).
The results show that formaldehyde is quickly released from mono- and dimethylol ethylene glycol and from the non-identified reaction products of ethylene glycol with formaldehyde. Further release thenoccurs more slowly. Formaldehyde hydrate and ethylene glycol could be demonstrated as hydrolysis products. The quick release at the beginning and the slower yet continuous release at later time points show that there are differences in the formaldehyde release rates of the individual constituents of EUF.
Similar results were obtained in a second study where products of hydrolysis were identified at different concentrations of EUF (100, 50, 10, 1, 0.25 and 0.025%) in phosphate buffer/D2O (pH 7) after 7 days of equilibrium adjustment. Increasing contents of the hydrolysis products ethylene glycol and formaldehyde were observed in parallel to increasing the D2O content. Simultaneously, the content of methylolated ethylene glycols decreased. Both in neat EUF and in diluted solutions reaction products of urea could be identified as urea derivatives but not specified. It can be recognized that on the one hand the reaction products of ethylene glycol with formaldehyde are completely hydrolyzed at low concentrations. On the other hand some of the reaction products of urea with formaldehyde and/or ethylene glycol are more stable under the conditions of the study.
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