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EC number: 240-383-3 | CAS number: 16291-96-6 An amorphous form of carbon produced by partially burning or oxidizing wood or other organic matter.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-07-08 to 2010-07-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to the principles of GLP (GLP certificate included) and according to OECD GL 117.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Principles of method if other than guideline:
- no aplicable
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Charcoal
- EC Number:
- 240-383-3
- EC Name:
- Charcoal
- Cas Number:
- 16291-96-6
- IUPAC Name:
- Carbón vegetal
- Details on test material:
- Name charcoal
Batch no. DP 07.2008/1
Appearance charcoal typic
Composition charcoal
CAS No. 16291-96-6
EINECS-No. 240-383-3
Purity C-Fix: 788.7%
Expiry date 01. Dec. 2030
Storage room temperature 20 ± 5 °C, keep away from humidity
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- ca. 0.3 - <= 1.474
- Temp.:
- 25 °C
- pH:
- ca. 5.5
- Remarks on result:
- other: Actually the determined log Pow is in the range of < 0.3 to 1.44
Any other information on results incl. tables
Table 2: Retention times, capacity factors k, and log Pow of the reference items
Compound |
Retention Time |
Retention Time (tr) RSD |
k |
log k |
log POW |
|
[min] |
[%] |
|
|
|
Thio urea |
1.506 |
0.059 |
0.0000 |
|
|
2-Butanone |
1.953 |
0.060 |
0.2969 |
-0.5274 |
0.30 |
Acetanilide |
2.214 |
0.070 |
0.4701 |
-0.3278 |
1.00 |
Acetophenone |
2.866 |
0.064 |
0.9032 |
-0.0442 |
1.70 |
Nitrobenzene |
3.410 |
0.036 |
1.2645 |
0.1019 |
1.90 |
Benzene |
4.824 |
0.098 |
2.2033 |
0.3431 |
2.10 |
Toluene |
7.632 |
0.125 |
4.0677 |
0.6094 |
2.70 |
Calibration Results:
A calibration function (log k versus log POW, linear fit) was determined using the literature values for POWof the reference items and the retention times in the six determinations.
Dead time was 1.506 ± 0.001 minutes, with a relative standard deviation (RSD) of 0.059 %.
The RSDs of the retention times of the reference items were all below 0.5 %.
Equation of the regression line :
log k = 0.4843 * log POW– 0.7572 with a correlation coefficient r2= 0.9587
Chromatogram of the test item
The chromatogram of the test item yields five peaks, one main peak (peak 1), two riders (peak 2 and peak 3) and two smaller peaks (peak 4 and peak 5).
Using the determined equation of the regression line and the calculated capacity factors for the test item, the log POWfor each of the 3 determinations was calculated by the following equation: log POW = (log k + 0.7572) / 0.4843. The corresponding log Pow values (mean of 3 determinations) are given in the following table
Table 3: Retention times , peak areas and corresponding log Pow of each of the peaks arised
in the chromatogram of the test item
Peak |
Mean Area |
Rel. Area % |
Mean retention time [min] |
Log POW |
1 |
2.7555 |
76.31 |
1.442 |
< 0.3 |
2 |
0.3336 |
9.24 |
1.840 |
0.213 ± 0.008 |
3 |
0.1192 |
3.3 |
2.312 |
1.003 ± 0.015 |
4 |
0.3599 |
9.97 |
2.869 |
1.474 ± 0.002 |
5 |
0.0428 |
1.19 |
7.148 |
2.748 ± 0.000 |
[1] mAU = milli absorbance units
These values are the means ± standard deviations of three independent determinations. The first peak lies within the dead time of the method and not within the range of log Pow’s of the reference items. Therefore, the corresponding log Pow should be stated as < 0.3 for peak 1. As peak 3 and 5 showed a relative area < 5%, they were considered as minor peaks and were not taken into account in the determination of log Pow of the test item. It is thus concluded that the test item charcoal (Probe 3: C-Fix = 88.7%) has a log Pow of < 0.3 -1.474.
Validity of the study
Table 4: Validity criteria and results
Peak |
Parameter |
Criterion |
Found |
Assessment |
1 |
Range (Max – Min log POW) |
< 0.1 |
not calculable |
not calculable |
Value within range of ref. items |
0.30 - 2.70 |
not calculable* |
not calculable |
|
2 |
Range (Max – Min log POW) |
< 0.1 |
0.016 |
valid |
Value within range of ref. items |
0.30 - 2.70 |
0.213 |
not valid |
|
3 |
Range (Max – Min log POW) |
< 0.1 |
0.028 |
valid |
Value within range of ref. items |
0.30 - 2.70 |
1.003 |
valid |
|
4 |
Range (Max – Min log POW) |
< 0.1 |
0.005 |
valid |
Value within range of ref. items |
0.30 - 2.70 |
1.474 |
valid |
|
5 |
Range (Max – Min log POW) |
< 0.1 |
0.001 |
valid |
Value within range of ref. items |
0.30 - 2.70 |
2.748 |
not valid |
* This peak lies within the dead time of the method and not within the range of log POWs of the reference items. Therefore the corresponding log Pow is stated as < 0.3.
** As there is only a minor deviation from this single validity criteria but all other validity criteria are met the study is considered to be valid.
Applicant's summary and conclusion
- Conclusions:
- It is concluded that the test item charcoal (Probe 3: C-Fix = 88.7%) has a log POW of < 0.3 -1.474. The result is related to the used charcoal extract (charcoal (Probe 3: C-Fix = 88.7%) with a nominal concentration of 224360 mg/L in methanol/water (75/25 % v/v) under the testing conditions (temperature = 25+1°C, pH = 5.5) used.
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