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Diss Factsheets
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EC number: 700-579-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Sepisol Fast Blue 85219 has been classified as acute toxicity category 4 with a LD 50 experimentally determined between 2000 and 300 mg/kg in rat.
Some concerns have been raised in regards to the toxicity per inhalation because of the relatively fine granulometry.
It was not reasonably possible to conclude but precautionnary measures should be taken so as to avoid exposition.
Key value for chemical safety assessment
Additional information
The substance Sepisol fast blue 85219 is a powder exhibiting a fine granulometry.
90% of the particles are below 268,5 µm; 50% below 69 µm and 10% below 8.7 µm. The size of 93.5 % of the total sample is less than 125 µm and most probably the MMAD is below 100 µm. It is then expected that this powder will be present all along the respiratory tract and will penetrate deeply in the lungs.
Following a in vivo assay, Sepisol Fast Blue 85219 has been classified as acute toxicity category 4 according to the CLP regulation.
Sepisol fast blue 85219 also shows a high Kow value which would suggest a good bioavaibilitity following a penetration through the alveoli. However the substance is a powder and is practically insoluble. As a result, it is unlikey that the substance will be solubilized. In this case the substance would remain as a particle state and would not be absorbed.
Moreover the vehicle (olive oil) used in the acute toxicity per os is not appropriate for this way of exposure.This would imply a change in the level of bioavailability.
As a result of the previous reasons, Sepisol fast blue 85219 is not expected to be also toxic per inhalation. The precautionary principle would recommend the warning of this possible effect inside safety documents.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.