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EC number: 700-801-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan-Jun 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Algae groth inhibition according to OECD 201 under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- The concentration of NaHCO3 was increased to be twice of that indicated in the Guideline 201. This concentration has been found to be optimal.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Bottom product of propylene oxide and styrene production
- IUPAC Name:
- Bottom product of propylene oxide and styrene production
- Details on test material:
- - Name of test material (as cited in study report): KORE grade V
- Substance type: UVCB
- Physical state: Brown viscous liquid
- Stability under test conditions: months
- Storage condition of test material: room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: Desmodesmus subspicatus CHODAT
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.98 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.24 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.717 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% CL 1.447 - 2.035 mg/L
Any other information on results incl. tables
Biological Part, Main Test
The followingindividual Cell Numbers were obtained:
Time t0 |
Control |
Nominal Concentrations |
|||||
0.50 mg/L |
1.00 mg/L |
2.00 mg/L |
4.00 mg/L |
8.00 mg/L |
|||
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
|
|
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
Mean Values: |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
2.64*103 |
Time t25h |
Control |
Nominal Concentrations |
|||||
0.50 mg/L |
1.00 mg/L |
2.00 mg/L |
4.00 mg/L |
8.00 mg/L |
|||
|
|
4.06*104 |
2.34*104 |
2.34*104 |
4.79*103 |
9.19*103 |
2.33*103 |
|
|
3.86*104 |
1.95*104 |
2.14*104 |
1.24*104 |
1.30*104 |
9.82*103 |
|
|
2.67*104 |
1.37*104 |
2.54*104 |
1.05*104 |
9.18*103 |
5.50*102 |
|
|
2.28*104 |
1.75*104 |
2.54*104 |
8.55*103 |
1.69*104 |
1.17*104 |
|
|
2.87*104 |
2.54*104 |
2.34*104 |
1.82*104 |
1.69*104 |
2.33*103 |
|
|
3.46*104 |
2.74*104 |
2.14*104 |
1.14*103 |
1.49*104 |
1.17*104 |
|
|
3.66*104 |
1.75*104 |
1.75*104 |
4.79*103 |
1.49*104 |
7.92*103 |
Mean Values: |
3.27*104 |
2.06*104 |
2.26104 |
8.61*103 |
1.36*104 |
6.63*103 |
Time t48h |
Control |
Nominal Concentrations |
|||||
0.50 mg/L |
1.00 mg/L |
2.00 mg/L |
4.00 mg/L |
8.00 mg/L |
|||
|
|
1.23*105 |
1.37*105 |
1.37*105 |
4.60*104 |
1.56*104 |
2.60*104 |
|
|
1.21*105 |
1.39*105 |
1.51*105 |
4.00*104 |
1.56*104 |
3.00*104 |
|
|
1.25*105 |
1.46*105 |
1.62*105 |
4.20*104 |
1.37*104 |
1.82*104 |
|
|
1.29*105 |
1.58*105 |
1.79*105 |
4.40*104 |
1.56*104 |
2.60*104 |
|
|
1.39*105 |
1.58*105 |
1.70*105 |
4.60*104 |
1.56*104 |
2.80*104 |
|
|
1.42*105 |
1.63*105 |
1.64*105 |
4.60*104 |
1.56*104 |
2.41*104 |
|
|
1.35*105 |
1.65*105 |
1.64*105 |
4.20*104 |
1.56*104 |
2.21*104 |
Mean Values: |
1.30*105 |
1.52*105 |
1.61*105 |
4.37*104 |
1.53*104 |
2.49*104 |
Time t72h |
Control |
Nominal Concentrations |
|||||
0.50 mg/L |
1.00 mg/L |
2.00 mg/L |
4.00 mg/L |
8.00 mg/L |
|||
|
|
5.42*105 |
6.32*105 |
6.09*105 |
1.53*105 |
1.62*104 |
1.56*104 |
|
|
5.67*105 |
6.81*105 |
6.97*105 |
1.45*105 |
1.24*104 |
1.75*104 |
|
|
5.86*105 |
7.18*105 |
7.59*105 |
1.47*105 |
1.24*104 |
1.17*104 |
|
|
6.15*105 |
7.87*105 |
7.88*105 |
1.51*105 |
1.24*104 |
2.93*104 |
|
|
6.55*105 |
7.65*105 |
8.12*105 |
1.45*105 |
1.43*104 |
1.75*104 |
|
|
6.66*105 |
8.25*105 |
7.97*105 |
1.51*105 |
1.05*104 |
1.56*104 |
|
|
6.62*105 |
8.21*105 |
8.39*105 |
1.18*105 |
1.24*104 |
1.95*104 |
Mean Values: |
6.13*105 |
7.47*105 |
7.57*105 |
1.44*105 |
1.29*104 |
1.81*104 |
Inhibition Values (Main Test)
NominalConcentration of the Test Item [mg/L] |
Growth Rates (day-1) |
Inhibition of the Growth Rate after 72h [%] |
Yield after 72h1) |
Inhibition of the Yield after 72h [%] |
Control (0) |
1.816 |
- |
6.11*105 |
- |
0.50 |
1.881 |
-3.62) |
7.44*105 |
-21.92) |
1.00 |
1.885 |
-3.82) |
7.55*105 |
-23.62) |
2.00 |
1.333 |
26.6 |
1.42*105 |
76.8 |
4.00 |
0.527 |
71.0 |
1.03*104 |
98.3 |
8.00 |
0.631 |
65.3 |
1.55*104 |
97.5 |
1)Yield = Cell number at time t72h– cell number at time t0
2)negative values indicate activation of growtApplicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 72h EC50 = 1.717 mg/L
72h EC50 = 1.717 mg/L - Executive summary:
The toxicity of„KORE grade V“towards algae was testedaccording to OECD-Guideline No. 201, in the Version dated 23-March 2006. The toxic effect was investigated by determination of the inhibition of the growth rate of the algae and the yield during the exposure period of 72 h. As the test item is partially poorly water-soluble, it was tested using aqueous extracts (“WAFs”) from up to 1000 mg test item/L (final concentration). The main test was performed using “WAFs” from 0.5 to 8 mg/L of the test item. As a conclusion of the analytical part of this study, recoveries of the concentrations determined after 72h were not all at ≥ 80% of those determined at time t0, and furthermore,the measured concentrations of the treatments deviated more than 20 % from the nominal values. Based on this, the reported effect concentrations refer to mean measured concentrations (geometric mean) of the measured concentrations.
From the results of the main test, toxic effects were determined with the following values:
On the Basis of the measured Concentrations tested
Yield (0 - 72 h)
EC10 0.408
95%-CL lower 0.342
upper 0.463
EC20 0.494
95%-CL lower 0.430
upper 0.546 EC50 0.713
95%-CL lower 0.667
upper 0.749
Yield LOEC 0.980
NOEC 0.240
Growth rate (0 - 72 h)
EC10 0.343
95%-CL lower 0.198
upper 0.487
EC20 0.597
95%-CL lower 0.405
upper 0.771
EC50 1.717
95%-CL lower 1.447
upper 2.035
Growth rate LOEC 0.980
NOEC 0.240
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