3,3,5-trimethylcyclohexan-1-one

Endpoint summary

Description of key information

Skin sensitisation:

The skin sensitisation potential for test chemical 3,3,5-trimethylcyclohexan-1-one is estimated using OECD QSAR toolbox version 3.3 The test substance 3,3,5-trimethylcyclohexan-1-one (CAS No. 873-94-9) is estimated to be non sensitising to skin of guinea pigs.

Based on the estimated result, test chemical 3,3,5-trimethylcyclohexan-1-one can be considered to be not sensitisingt to skin and hence does not classify in skin sesntisation catergory as per CLP regulation.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

Skin sensitisation:

Different studies for the 3,3,5-trimethylcyclohexan-1-one (873-94-9) and its read across substances (CAS 78-59-1) and (CAS 3452-97-9) were reviewed for skin sensitization potential and the information for the same are as follows:

For target, the skin sensitisation potential for is estimated using OECD QSAR toolbox version 3.3 The test substance 3,3,5-trimethylcyclohexan-1-one (CAS No. 873-94-9) is estimated to be non sensitising to skin of guinea pigs. Based on the estimated result, test chemical 3,3,5-trimethylcyclohexan-1-one can be considered to be not sensitizing to skin and hence does not classify in skin sensitisation category as per CLP regulation.

Another prediction done using the Danish (Q)SAR Database, the skin sensitization was estimated in guinea pig and human for 3,3,5-trimethylcyclohexan-1-one .Using Battery algorithm model of Danish QSAR, Allergic Contact Dermatitis for 3,3,5-trimethylcyclohexan-1-one was estimated to be not sensitizing when applied to human and guinea pig skin. Based on the estimated result, test chemical 3,3,5-trimethylcyclohexan-1-one can be considered to be not sensitising to skin and hence does not classify in skin sesntisation catergory as per CLP regulation.

In an experimental study for RA (CAS 78-59-1) Magnusson-Kligman test i.e. guinea pig maximisation test was performed for testing the skin sensitization potential of the substance 3,5,5-trimethylcyclohex-2-enone. The test substance 3,5,5-trimethylcyclohex-2-enone (Isophorone), administered at a concentration of 10% intradermally (in maize germ oil) and 100% topically to female guinea-pigs. The substance did not showed skin sensitizing potential. Based on the above test, the test chemical 3,5,5-trimethylcyclohex-2-enone can be considered to be non sensitising to skin and is not classified under the category of skin sensitisation as per CLP regulation.

Further in an another experimental study from second RA (CAS 3452-97-9), Human repeated insult patch test (HRIPT) was performed for testing the skin sensitization potential of the substance 3,5,5-trimethylhexan-1-ol. The test substance 3,5,5-trimethylhexan-1-ol, administered at a concentration of 8%. The substance did not showed skin sensitizing potential. Based on the above test, the test chemical 3,5,5-trimethylhexan-1-ol can be considered to be non sensitising to skin and is not classified under the category of skin sensitisation as per CLP regulation.

Based on the above results from the test substance 3,3,5-trimethylcyclohexan-1-one and the read across substances 3,5,5-trimethylcyclohex-2-enone and 3,5,5-trimethylhexan-1-ol it can be considered that the test substance 3,3,5-trimethylcyclohexan-1-one is not classified under the category of skin sensitisation as per CLP regulation.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

Based on the above studies and predictions on 3,3,5-trimethylcyclohexan-1-one, it can be concluded that 3,3,5-trimethylcyclohexan-1-one can be considered as non skin sensitiser as per CLP regulation.