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EC number: 201-487-4 | CAS number: 83-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a former study report (Bayer 1978) single oral application of up to 1200 mg/kg bw to 10 male Wistar rats per dose group and observation for 14 days is described. The LD50 is 660 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: short report but sufficient information to be taken into account
- Principles of method if other than guideline:
- Single oral application of 5 different doses of test substance in lutrol to 10 male Wistar rats/dose . Observation for clinical signs and mortal was done for: 14 days; calculation of LD50 was done according to Fink und Hund (1965): Arzneimittel Forschung 15, 624
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- body weight at study start: 160 - 180 g
5 aninmals/cage
no further data given - Route of administration:
- oral: gavage
- Vehicle:
- other: lutrol
- Details on oral exposure:
- Single oral application of different doses in lutrol to 10 male rats/dose
- Doses:
- 100, 500, 800, 1000, 1200 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- Single oral application of 5 different doses of test substance in lutrol to 10 male Wistar rats/dose .
Observation period for clinical signs and mortality: 14 days.
Calculation of LD50: according to Fink und Hund (1965): Arzneimittel Forschung 15, 624 - Statistics:
- Calculation of LD50 according to Fink und Hund (1965): Arzneimittel Forschung 15, 624
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 660 mg/kg bw
- 95% CL:
- >= 480 - <= 790
- Remarks on result:
- other: tremor, cramps and prone position
- Mortality:
- 100 mg animals survived
500 mg-group: 3/10 within 2-3 d after application
800 mg-group 5/10 within 2-3 days after application
1000 mg-group 9/10 within 2 days after application
1200 mg-group: 10/10 within 1 h after application - Clinical signs:
- other: tremor, prone position, cramps, crying
- Gross pathology:
- no data
- Other findings:
- no data
- Executive summary:
Single oral application of up to 1200 mg/kg bw to 10 male Wistar rats per dose group and observation for 14 days. 100 mg/kg bw was tolerated without mortality or clinical signs. All other animals displayed tremor, cramps. prone position and cry before death occurred: 2 -3/10 at 500 mg/kg bw up to 10/10 at the highest test dose.. LD50 is 660 mg/kg bw
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 660 mg/kg bw
- Quality of whole database:
- available data include every endpoint
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: oral application
There are 2 studies available which should be taken into account with regard to classification and labeling.
In an former study report (Bayer 1978) single oral application of up to 1200 mg/kg bw to 10 male Wistar rats per dose group and observation for 14 days is described. 100 mg/kg bw was tolerated without mortality or clinical signs. All other animals displayed tremor, cramps, prone position and cry before death occurred: 2 -3/10 at 500 mg/kg bw up to 10/10 at the highest test dose. The LD50 is 660 mg/kg bw. Based on these result the test substance was provionally classied/labeled by manufacturer/importer with R 22 = harmfull if swallowed.
In 2010 Scientific Committee on Consumer Safety (SCCS) reported of male and female rats which were given 2000 mg/kg bw test substance as single application and were observed for 14 days according to OECD TG 423 and GLP. No mortality occurred. The reported clinical findings within the first two days included hunched posture and piloerection. The LD50 value of 1,5 -naphthalenediol in Wistar rats was established to exceed 2000 mg/kg bw. However, this is a secondary citation and the individual animal data are not available.
Therefore , and due to the discrepancy of the available results, we propose not to change the classification of 1,5-naphthalenediol and to allocate 1,5-naphthalenediol to Category 4 , H302 (= harmfull if swallowed) of the acute oral toxicity group in GHS/CLP Regulation(EC) 1272/2008
Justification for selection of acute toxicity – oral endpoint
reliable study although not according to GLP
Justification for classification or non-classification
Based on the considerations above, and due to the discrepancy of the available results, we propose not to change the classification of 1,5-naphthalenediol and to allocate 1,5-naphthalenediol to Category 4 , H302 (= harmfull if swallowed) of the acute oral toxicity group in GHS/CLP Regulation(EC) 1272/2008
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