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Reaction product of {mixture of [poly(1~4)chlorosulfonylphthalocyaninato-N29,N30,N31,N32]copper(Ⅱ) and [poly(1~3) chlorosulfonyl (tribenzo[b,g,l]pyrido[2,3-q]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)] copper(Ⅱ) and [poly(1~2) chlorosulfonyl (dibenzo[b,g(or b,l)]dipyrido [2,3(or 3,2)-l,q(or g,q)]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)] copper(Ⅱ) and [monochlorosulfonyl (benzo[b]tripyrido [2,3(or 3,2)-g,l,q]-5,10,15,20-tetraazaporphyrinato-N21,N22,N23,N24)]copper(Ⅱ) }and 2-[4-(2-aminoethylamino)-6-(benzylamino)-1,3,5-triazin-2-ylamino]benzene-1,4-disulfonic acid, and ammonia water and sodium chloride
EC number: 700-815-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 21 - August 19, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to current OECD test guidelines and GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- E-C104
- IUPAC Name:
- E-C104
- Details on test material:
- - Name of test material (as cited in study report): E-C104
- Physical state: Blue powder, solid
- Lot/batch No.: MB-1
- Expiration date of the lot/batch: July 6, 2015
- Storage condition of test material: Room temperature, dark place
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Japan, Inc. (Hino breeding center)
- Age at study initiation: 9 weeks
- Weight at study initiation: 186.1-198.8 g
- Fasting period before study: From the evening on the day before the administration (approx 18 hours predose) to about 3 hours postdose.
- Housing: Stainless steel cages (W226xD346xH198 mm), stainless steel racks and feeders, one animal per cage
- Diet (ad libitum): Pellet diet (CRF-1, Oriental Yeast Co., Ltd.) (each lot analysed: contaminants confirmed to be within acceptable limits established by the test facility)
- Water (ad libitum): Well water (analysed every 6 months: contaminants confirmed to be within acceptable limits in compliance with waterworks law, Japan)
- Acclimation period: 6 days for experiment 1 and 8 days for experiment 2
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23.6-24.6
- Humidity (%): 44.9-61.3
- Air changes (per hr): 10 to 20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: test substance solved to make a dosing solution at a concentration of 100 mg/ml
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg
DOSAGE PREPARATION: The dosing volumes for individual animals were calculated on the basis of the body weight measured just before administration.
CLASS METHOD
- Rationale for the selection of the starting dose: The lethal dose of a similar substance was reported to be 2000 mg/kg or above. Therefore, the dose level for the first administration was set at 2000 mg/kg, which is the maximum dose recommended in the guideline applied to this study. As a result, as no death or moribundity was observed on the day after the first administration the dose level for the second administration was also set at 2000 mg/kg. - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 3 females in each of 2 experiments
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality and clinical signs were observed before the dosing (Day 1, day of initial administration), 30 min, 1, 3, and 5 hours postdose on Day 1 and once daily for 14 days thereafter. Body weight was measured just before the administration (Day 1) and on Days 4, 8, and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: none - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were noted in any animal in experiment 1 and 2.
- Clinical signs:
- other: Test substance mixed feces was observed in all animals from 3 hours on Day 1 to Day 3 or 4, and chromaturia (bluish) was observed in all animals on Day 2 and 3 in experiment 1 and 2. These changes were attributed to the test substance as this is a blue po
- Gross pathology:
- No abnormalities were noted in any animal in experiment 1 or 2.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of E-C104 in rats was estimated to be 2000 mg/kg or above under the conditions of this study (OECD 423).
- Executive summary:
A single oral administration of E-C104 (dissolved in water) by gavage was conducted to female 9 weeks old Crl:CD(SD) rats to evaluate its acute oral toxicity in accordance with the OECD test guideline 423. A dose of 2000 mg/kg was employed for the first and second administration to each three rats. As a result, there was no mortality, body weight gain effects, or necropsy findings. Clinical signs were restricted to test substance mixed feces and chromaturia (bluish). In conclusion, the LD50 of E-C104 in rats was estimated to be 2000 mg/kg or above under the conditions of this study.
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