Registration Dossier
Registration Dossier
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EC number: 215-951-9 | CAS number: 1459-93-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In the Key Study entitled "Dimethyl Isophthalate: Acute Toxicity to the Cladoceran, Daphnia magna, Determined Under Static Test Conditions"
(Bergfield -ABC, 2012) the estimated 48-h EC50 value was 50.0 mg/L, with 95% confidence limits of 43.9 mg/L and 56.9 mg /L; the 48-h NOEC was 39.9 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 50 mg/L
Additional information
Vertellus Performance Materials, Inc. contracted ABC Laboratories, Inc. (Bergfield -ABC, 2012) to perform a 48 -hour static toxicity test to the freshwater invertebrate, Daphnia magna, exposed to dimethyl isophthalate. The criterion for effect was immobilization.
The estimated 24-hour EC50 value, based on mean measured concentrations, was 74.1 mg/L, with 95% confidence limits of 59.1 mg/L and 92.8 mg /L. The estimated 48 -hour EC50 value, based on mean measured concentrations, was 50.0 mg/L, with 95% confidence limits of 43.9 mg/L and 56.9 mg /L. The slope of the 48‑hour concentration-response line could not be calculated. There were no sublethal effects noted in the control or test substance treatments during the definitive test. The 48-hour NOEC was 39.9 mg/L, based on mean measured concentrations and a lack of statistically significant immobility or sublethal effects at this and all lower test substance concentrations.
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