Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-801-5 | CAS number: 110-76-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02. Jun 1978 - 25. Aug 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- BASF-Test. The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior treatment and thereafter, day 3, day 7 and day 13 post-treatment. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.
The LD50 value was estimated on the basis of the observed mortalities. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethoxyethylamine
- EC Number:
- 203-801-5
- EC Name:
- 2-ethoxyethylamine
- Cas Number:
- 110-76-9
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-ethoxyethylamine
- Details on test material:
- - Name of test material (as cited in study report): 2-Aethoxyaethylamin
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight at study initiation: male. 226 g (mean), female: 176 g (mean)
- Fasting period before study: 16-20 h
- Diet: Herlian MRH (Eggersmann KG, Rinteln) ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.81, 10, 12.1, 14.7, 21.5% - Doses:
- 681, 1000, 1210, 1470, 2150 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: days 0, 3, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 950 mg/kg bw
- Mortality:
- see detail in remarks on results.
- Clinical signs:
- other: 2150 mg/kg bw: 15 min post application: irregular respiration, apathy, staggering, spastic gait. 4 h post application: pain reflex, ruffled fur, feces discoloured, exsiccosis, narcosis. 1470 mg/kg bw: 15 min post application: spastic gait, staggering.
- Gross pathology:
- 2150 mg/kg bw:
Heart: diletation on the right ventricle, congestion.
Stomach: strong diffuse erythema of the mucosa.
Intestine: atonic, erythema of the mucosa, diarrhetic content.
1470 mg/kg bw:
Heart: diletation on the right ventricle, congestion.
Stomach: strong diffuse erythema of the forestomach mucosa.
Intestine: atonic, erythema of the mucosa, dark content.
Lung: partly acute swelling.
Peritoneum: ascites
1210 mg/kg bw:
Peritoneum: diffuse erythema, hemorrhagic gastritis
Intestine: atonic, erythema, dark diarrhetic content.
1000 mg/kg bw:
Heart: diletation on the right ventricle, congestion.
Stomach: erythema of the glandular stomach.
Intestine: atonic, erythema of the mucosa, dark diarrhetic content.
Sacrificed animals: without abnormalities.
Any other information on results incl. tables
Mortality:
| Dose (mg/kg bw) | Gender | dead within 1h | dead within 1 day | dead within 2 days | dead within 7 days | dead within 14 days | |
| 2150 | male | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | |
| female | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | ||
| 1470 | male | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | |
| female | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | ||
| 1210 | male | 0/5 | 4/5 | 4/5 | 4/5 | 4/5 | |
| female | 0/5 | 5/5 | 5/5 | 5/5 | 5/5 | ||
| 1000 | male | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | |
| female | 0/5 | 3/5 | 3/5 | 3/5 | 3/5 | ||
| 681 | male | 0/5 | 1/5 | 1/5 | 1/5 | 1/5 | |
| female | 0/5 | 1/5 | 1/5 | 1/5 | 1/5 |
The test substance caused moderate toxicity (including mortality) after a single ingestion and caused local irritations to exposed tissues.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
