Registration Dossier
Registration Dossier
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EC number: 500-687-1 | CAS number: 162303-51-7
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as substance is hydrolytically unstable. Based on the rapid hydrolysis, and the ready biodegradability and low aquatic toxicity of the main decomposition product, this substance can be considered as readily degradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Testing of biodegradability of titanium tetrabutanolate is not scientifically justified as it is hydrolytically unstable. When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than n-butanol and hydrated titanium dioxides (half-life less than 2 hours, OECD 111; Brekelmans 2013). In addition, biodegradability testing is not necessary as all the decomposition products have been identified. The most relevant degradation product (n-butanol) is also readily biodegradable. The other environmentally non-hazardous degradation product (TiO2) is inorganic and insoluble and therefore not relevant to be considered for this endpoint.
Several studies have been conducted to assess the biodegradation of n-butanol in water and treated sewage. Aerobic biodegradation in unadapted sludge was found to be 37 % of ThOD after 24 hours (Gerhold and Malaney 1966). Aerobic biodegradation in adapted sludge was measured to be 44 % of ThOD after 23 hours (McKinney and Jeris 1955). The 20-d biodegradation-% of n-butanol using settled domestic wastewater was 92 % in freshwater and 82 % in sythetic sea water at nominal test concentrations of 3, 7 and 10 mg/l (Price et al. 1974). Based on these studies n-butanol is readily biodegradable under aerobic conditions.
Based on the information on aquatic toxicity and biodegradation of the decomposition products, and the rapid hydrolysis of the target substance, the abiotic degradation can be used to demonstrate fast degradation of this substance for the purposes of C&L.
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