Registration Dossier
Registration Dossier
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EC number: 234-205-3 | CAS number: 10595-60-5
Endpoint summary
Administrative data
Description of key information
LD50(oral) = ca. 1673 mg/kg bw (US EPA, 2003)
LD50(dermal) = ca. 2500 mg/kg bw (US EPA, 1991)
Key value for chemical safety assessment
Additional information
Acute oral toxicity
Groups of five male and five female fasted Albino rats were dosed with the undiluted sample at dosage levels of 4, 2, and
1 ml/kg. Animals were observed for signs of toxicity and mortality. Weight changes were measured in 14 day study
period. Necropsies were performed on all animals upon death or 14 days after dosing. The study was comparable to OECD 401 guideline. All animals dosed at 4.0 ml/kg died within one day of dosing. Six animals died from one to nine days after dosing in the 2.0
ml/kg group. No animals treated with 1 ml/kg died. The combined oral LD50 was ca. 1673 mg/kg bw.
Acute dermal toxicity
An acute dermal toxicity study was conducted on twelve male and twelve female albino rabbits. The study was comparable to OECD 402 guideline. There were four males and four females per each of three treatment groups. The exposure areas of two males and two females from each treatment group were lightly abraded.
The dose levels were 0, 1250 and 2500 mg/kg bw. The control animals were wrapped, washed and observed in an identical manner as the other animals but were untreated and did not receive the test material or any other material. Four high dose animals died during the study. The acute dermal LD50 is approximately 2500 mg/kg bw when administered to albino rabbits.
Justification for classification or non-classification
Based on the available acute oral and dermal toxicity studies, the substance was classified R22 (according to Directive 67/548/EEC) and Acute toxicity oral Cat. 4 (according to CLP).
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