Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 607-997-7 | CAS number: 26776-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-10-12 to 2007-12-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions: high concentration of solvent, no substance specific analytical monitoring
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- (1992)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- Measurement of dissolved organic carbon (DOC) after 0, 24, 48, 72 and 96 hours
- Vehicle:
- no
- Details on test solutions:
- A stock solution was prepared to give the desired test concentration. To achieve this 500.8 mg of the test item were added to 5 litres of dilution water and treated for 60 seconds at 8000 rpm with an ultra turrax and afterwards stirred for 3 hours on a magnetic stirrer. Finally undissolved particles of the test item were removed by filtration using a folded filter of pore size 7-12 μm. The resulting filtrate was coloured slightly milky white.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Source: Aqua KloeGer (Germany)
Stock held and acclimatised to test conditions since 2007-09-18
Feeding discontinued 24 hours proir to test start
Mean standard length: 3.4 cm (S.D. = 0.14 cm)
Loading: 0.44 g body weight per litre - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 15.2° dH (=271 mg/l CaCO3)
- Test temperature:
- 21.9-22.8°C
- pH:
- 7.5-7.9
- Dissolved oxygen:
- above 60% of the air saturation value: 7.4 mg/L to 8.9 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L solution = 72 mg/l oligomer
measured (DOC): 14.4 mg/L (0h), 15.35 mg/L (24h), 14.91 mg/L (48h), 14.61 mg/L (72h), 13.21 mg/L (96h)
For a solution of 28 mg solvent / 100 ml test water a DOC of 15.3 mg/l is expected (54.53 % carbon in molecular formula). - Details on test conditions:
- 7 animals per test concentration were held in glass aquaria holding 5 L of test media. The aquaria were gently aerated via narrow glass tubes to maintian the dissolved oxygen above 60% of the air saturation value. No feeding took place during the exposure period and the test media were not exchanged (static system). The fish were held in a 16 h light : 8 h dark cycle.
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- At a limit test concentration of 100 mg solution/L one out of seven fish died. Typically this would trigger re-testing with several test concentrations. As none of the remaining 6 fish showed any symptoms of toxicity it can be concluded that the LC 50 is > 100 mg solution/L and no re-testing was performed.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test solution showed no toxic effects on fish at a nominal concentration of 100 mg/L, corresponding to 72 mg 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/L.
- Executive summary:
- A study was performed to assess the acute toxicity of a 72 % solution of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane in 2-methoxy-1-methylethylacetate to Danio rerio under static conditions. The study was conducted in accordance with EEC Methods for Determination of Ecotoxicity in Directive 92/69/EEC (O.J. No. L383A, 1992) Part C, Method 1 'Acute toxicity for Fish' which is in most parts equivalent to the OECD Guideline for Testing of Chemicals No. 203 'Fish, Acute Toxicity Test' (1992). A group of seven fish of mostly the recommended size was exposed to a limit test concentration of nominally 100 mg test item /L test water. Auxiliaries used to prepare the test media were an ultra turrax, a magnetic stirrer and folded filters. Observations were made on the number of dead fish and the incidence of sub-lethal effects after 2, 24, 48, 72 and 96 hours of exposure. At a limit test concentration of 100 mg/L one out of seven fish died. Typically this would trigger re-testing with several test concentrations. As none of the remaining 6 fish showed any symptoms of toxicity it can be concluded that the LC 50 is > 100 mg test item/L (72 mg 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/L) and no re-testing was performed. All results are expressed in terms of nominal concentrations. The determination of the DOC gave results corresponding to the (nominal) 28 mg 2-methoxy-1-methylethylacetate/L while insoluble oligomer was removed before test start.
Reference
Description of key information
A study was performed to assess the acute toxicity of a 72 % solution of 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane in 2-methoxy-1-methylethylacetate to Danio rerio under static conditions. The study was conducted in accordance with EEC Methods for Determination of Ecotoxicity in Directive 92/69/EEC (O.J. No. L383A, 1992) Part C, Method 1 'Acute toxicity for Fish' which is in most parts equivalent to the OECD Guideline for Testing of Chemicals No. 203 'Fish, Acute Toxicity Test' (1992). A group of seven fish of mostly the recommended size was exposed to a limit test concentration of nominally 100 mg test item /L test water. Auxiliaries used to prepare the test media were an ultra turrax, a magnetic stirrer and folded filters. Observations were made on the number of dead fish and the incidence of sub-lethal effects after 2, 24, 48, 72 and 96 hours of exposure.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
At a limit test concentration of 100 mg/L one out of seven fish died. Typically this would trigger re-testing with several test concentrations. As none of the remaining 6 fish showed any symptoms of toxicity it can be concluded that the LC 50 is > 100 mg test item/L (72 mg 2H-Azepin-2-one, hexahydro-, polymer with 1,6-diisocyanatohexane/L) and no re-testing was performed. All results are expressed in terms of nominal concentrations. The determination of the DOC gave results corresponding to the (nominal) 28 mg 2-methoxy-1-methylethylacetate/L while insoluble oligomer was removed before test start.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.